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Keywords: Primary cilia
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Journal Articles
Dis Model Mech (2022) 15 (8): dmm049611.
Published: 16 August 2022
... an avian model, we report a novel molecular mechanism (disruptions in the FGF23–PTH axis resulting in reduced calcium uptake in the developing mandible) and potential treatment for ciliopathic micrognathia. Primary cilia Ciliopathies FGF C2CD3 Micrognathia talpid 2 National Institute...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (7): dmm044289.
Published: 30 July 2020
... and Hh signalling are suppressed during ADM in cells expressing oncogenic KRAS. We show that ciliogenesis fails due to ectopic activation of the cilium disassembly pathway, which is mediated by AurkA, a direct transcriptional target of KRAS. Inhibition of AurkA is able to rescue primary cilia and restore...
Journal Articles
Dis Model Mech (2016) 9 (7): 789–798.
Published: 1 July 2016
...Damon T. Jacobs; Luciane M. Silva; Bailey A. Allard; Michael P. Schonfeld; Anindita Chatterjee; George C. Talbott; David R. Beier; Pamela V. Tran ABSTRACT Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 855–866.
Published: 1 August 2015
.... A. ( 2010 ). A primary cilia-dependent etiology for midline facial disorders . Hum. Mol. Genet.   19 , 1577 - 1592 . 10.1093/hmg/ddq030 Carmona-Fontaine , C. , Theveneau , E. , Tzekou , A. , Tada , M. , Woods , M. , Page , K. M. , Parsons , M. , Lambris , J. D...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (6): 527–541.
Published: 1 June 2015
... axis during developmental signalling and disruption in ciliopathy disease state. TMEM67 Meckelin MKS3 Wnt signalling Planar cell polarity PCP Stereocilia Kinocilia Primary cilia Hair bundle Ciliopathy Primary cilia are microtubule-based organelles that sense and transduce...
Includes: Supplementary data