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Keywords: Primary cilia
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Journal Articles
In collection:
Dis Model Mech (2020) 13 (7): dmm044289.
Published: 30 July 2020
... and Hh signalling are suppressed during ADM in cells expressing oncogenic KRAS. We show that ciliogenesis fails due to ectopic activation of the cilium disassembly pathway, which is mediated by AurkA, a direct transcriptional target of KRAS. Inhibition of AurkA is able to rescue primary cilia and restore...
Journal Articles
Dis Model Mech (2016) 9 (7): 789–798.
Published: 01 July 2016
...Damon T. Jacobs; Luciane M. Silva; Bailey A. Allard; Michael P. Schonfeld; Anindita Chatterjee; George C. Talbott; David R. Beier; Pamela V. Tran ABSTRACT Primary cilia extend from the plasma membrane of most vertebrate cells and mediate signaling pathways. Ciliary dysfunction underlies...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 855–866.
Published: 01 August 2015
... in oral-facial-digital syndrome. Primary cilia Craniofacial Neural crest talpid 2 Ciliopathies Chicken Oral-facial-digital syndrome Primary cilia are non-motile, microtubule-based organelles that function as cellular antennas to coordinate the transduction of several signaling...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (6): 527–541.
Published: 01 June 2015
.... Highlighted Article: TMEM67 is a receptor of non-canonical Wnt signalling, implicating the Wnt5a-TMEM67-ROR2 axis during developmental signalling and disruption in ciliopathy disease state. TMEM67 Meckelin MKS3 Wnt signalling Planar cell polarity PCP Stereocilia Kinocilia Primary cilia Hair...
Includes: Supplementary data