... attributed. Summary: By compiling data on primary cilia-associated genes, their corresponding mouse and zebrafish alleles, and phenotypes, we provide an editable, Excel-based tool to help researchers identify and prioritize genes for study. Polycystic kidney disease Cilia Mouse alleles...

... stage. Notably, adult fish with Wwtr1 overexpression developed phenotypes similar to those of human polycystic kidney disease (PKD). Overall, our analyses revealed roles of Stk3 and Wwtr1 in renal cyst formation. Using a pharmacological approach, we further demonstrated that Stk3-deficient zebrafish...