... brain function. Increasing evidence suggests multiple roles for astrocytes in Parkinson's disease, nudging a shift in the research focus, which historically pivoted around ventral midbrain dopaminergic neurons (vmDANs). Studying human astrocytes and other cell types in vivo remains challenging. However...

... common genetic risk factor for Parkinson's disease (PD). Moreover, sporadic PD patients also have a substantial reduction of GCase activity. Genetic variants of SMPD1 are also overrepresented in PD cohorts, whereas a reduction of its encoded enzyme (acid sphingomyelinase or ASM) activity is linked...

...Marco Travaglio; Filippos Michopoulos; Yizhou Yu; Rebeka Popovic; Edmund Foster; Muireann Coen; L. Miguel Martins ABSTRACT Parkinson's disease (PD), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (SN). Mitochondrial...

...Emma L. Lane; Mariah J. Lelos ABSTRACT First-in-human clinical trials have commenced to test the safety and efficacy of cell therapies for people with Parkinson's disease (PD). Proof of concept that this neural repair strategy is efficacious is based on decades of preclinical studies and clinical...

... glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and accumulation of alpha-synuclein (aSyn). To enable a better understanding of the relationship between aSyn and GCase activity, we...

...Zhao-Feng Li; Lei Cui; Mi-Mi Jin; Dong-Yan Hu; Xiao-Gang Hou; Shu-Shu Liu; Xiong Zhang; Jian-Hong Zhu ABSTRACT Parkinson's disease (PD) is associated with α-synuclein-based Lewy body pathology, which has been difficult to observe in conventional two-dimensional (2D) cell culture and even in animal...

...Regev Landau; Reut Halperin; Patti Sullivan; Zion Zibly; Avshalom Leibowitz; David S. Goldstein; Yehonatan Sharabi ABSTRACT Recent reports indicate that Parkinson's disease (PD) involves specific functional abnormalities in residual neurons – decreased vesicular sequestration of cytoplasmic...

...Stephanie M. Pütz; Jette Kram; Elisa Rauh; Sophie Kaiser; Romy Toews; Yi Lueningschroer-Wang; Dirk Rieger; Thomas Raabe ABSTRACT Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural instability, and also non-motor symptoms such as depression, anxiety, sleep...

...Barbara Calamini; Nathalie Geyer; Nathalie Huss-Braun; Annie Bernhardt; Véronique Harsany; Pierrick Rival; May Cindhuchao; Dietmar Hoffmann; Sabine Gratzer ABSTRACT Parkinson's disease (PD) is a fatal neurodegenerative disorder that is primarily caused by the degeneration and loss of dopaminergic...

... a valuable tool for drug development. Here, we have developed a zebrafish model of Parkinson's disease (PD) together with a novel method to screen for movement disorders in adult fish, pioneering a more efficient drug-testing route. Mutation of the PARK7 gene (which encodes DJ-1) is known to cause monogenic...

... in the synucleinopathies, a group of neurodegenerative disorders that includes Parkinson's disease. While there is a clear link between protein misfolding and neuronal vulnerability, the precise pathogenic mechanisms employed by disease-associated α-synuclein are unresolved. Here, we studied the pathogenicity of misfolded...

...Urmas Roostalu; Casper B. G. Salinas; Ditte D. Thorbek; Jacob L. Skytte; Katrine Fabricius; Pernille Barkholt; Linu M. John; Vanessa Isabell Jurtz; Lotte Bjerre Knudsen; Jacob Jelsing; Niels Vrang; Henrik H. Hansen; Jacob Hecksher-Sørensen ABSTRACT Parkinson's disease (PD) is a basal ganglia...

...Suwei Chen; Sarah J. Annesley; Rasha A. F. Jasim; Vanessa J. Musco; Oana Sanislav; Paul R. Fisher ABSTRACT The loss of function of DJ-1 caused by mutations in DJ1 causes a form of familial Parkinson's disease (PD). However, the role of DJ-1 in healthy and in PD cells is poorly understood. Even its...

...Victorio M. Pozo Devoto; Tomas L. Falzone ABSTRACT The distinctive pathological hallmarks of Parkinson's disease are the progressive death of dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α-synuclein protein. Several lines of evidence from the study of sporadic...

... Schrempf; Kathrin Reetz; Peter Young; David Vadasz; Achilleas S. Frangakis; Evelin Schröck; Helmuth Steinmetz; Marina Jendrach; Udo Rüb; Ayşe Nazlı Başak; Wolfgang Oertel; Georg Auburger ABSTRACT Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation...

... pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucleolar activity in pre-symptomatic digenic models of Parkinson's disease (PD) that model the multifactorial aetiology of this disease. To this end, we analysed a novel...

..., development and adulthood. The inability of cells to regulate Ca 2+ can lead to pathological conditions that ultimately culminate in cell death. One such pathological condition is manifested in Parkinson's disease, the second most common neurological disorder in humans, which is characterized...

... of post-mortem Parkinson's disease (PD) brains, pharmacological and genetic models of PD have suggested that two fundamental interacting cellular processes are impaired – proteostasis and mitochondrial respiration. We have re-examined the role of mitochondrial dysfunction in lymphoblasts isolated from...

... that the original work is properly attributed. Summary: The results suggest that the bromocriptine alginate nanocomposite is potent in reducing the symptoms of Parkinson's disease in a transgenic fly model of the disease. Bromocriptine Nanocomposite Parkinson's disease Dopamine agonists can...

...Víctor Fernández-Dueñas; Jaume J. Taura; Martin Cottet; Maricel Gómez-Soler; Marc López-Cano; Catherine Ledent; Masahiko Watanabe; Eric Trinquet; Jean-Philippe Pin; Rafael Luján; Thierry Durroux; Francisco Ciruela Parkinson’s disease (PD) is a dopaminergic-related pathology in which functioning...