1-20 of 22
Keywords: Parkinson's disease
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Dis Model Mech (2023) 16 (6): dmm049980.
Published: 23 June 2023
... brain function. Increasing evidence suggests multiple roles for astrocytes in Parkinson's disease, nudging a shift in the research focus, which historically pivoted around ventral midbrain dopaminergic neurons (vmDANs). Studying human astrocytes and other cell types in vivo remains challenging. However...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2023) 16 (6): dmm049954.
Published: 10 May 2023
... common genetic risk factor for Parkinson's disease (PD). Moreover, sporadic PD patients also have a substantial reduction of GCase activity. Genetic variants of SMPD1 are also overrepresented in PD cohorts, whereas a reduction of its encoded enzyme (acid sphingomyelinase or ASM) activity is linked...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (1): dmm049727.
Published: 25 January 2023
...Marco Travaglio; Filippos Michopoulos; Yizhou Yu; Rebeka Popovic; Edmund Foster; Muireann Coen; L. Miguel Martins ABSTRACT Parkinson's disease (PD), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (SN). Mitochondrial...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (10): dmm049543.
Published: 27 September 2022
...Emma L. Lane; Mariah J. Lelos ABSTRACT First-in-human clinical trials have commenced to test the safety and efficacy of cell therapies for people with Parkinson's disease (PD). Proof of concept that this neural repair strategy is efficacious is based on decades of preclinical studies and clinical...
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2022) 15 (6): dmm049192.
Published: 25 May 2022
... glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and accumulation of alpha-synuclein (aSyn). To enable a better understanding of the relationship between aSyn and GCase activity, we...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2021) 14 (6): dmm047811.
Published: 14 June 2021
...Stephanie M. Pütz; Jette Kram; Elisa Rauh; Sophie Kaiser; Romy Toews; Yi Lueningschroer-Wang; Dirk Rieger; Thomas Raabe ABSTRACT Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural instability, and also non-motor symptoms such as depression, anxiety, sleep...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2020) 13 (1): dmm040899.
Published: 17 January 2020
... in the synucleinopathies, a group of neurodegenerative disorders that includes Parkinson's disease. While there is a clear link between protein misfolding and neuronal vulnerability, the precise pathogenic mechanisms employed by disease-associated α-synuclein are unresolved. Here, we studied the pathogenicity of misfolded...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2017) 10 (9): 1075–1087.
Published: 1 September 2017
...Victorio M. Pozo Devoto; Tomas L. Falzone ABSTRACT The distinctive pathological hallmarks of Parkinson's disease are the progressive death of dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α-synuclein protein. Several lines of evidence from the study of sporadic...
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2017) 10 (5): 619–631.
Published: 1 May 2017
... Schrempf; Kathrin Reetz; Peter Young; David Vadasz; Achilleas S. Frangakis; Evelin Schröck; Helmuth Steinmetz; Marina Jendrach; Udo Rüb; Ayşe Nazlı Başak; Wolfgang Oertel; Georg Auburger ABSTRACT Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Neurodegeneration
Dis Model Mech (2017) 10 (5): 519–535.
Published: 1 May 2017
..., development and adulthood. The inability of cells to regulate Ca 2+ can lead to pathological conditions that ultimately culminate in cell death. One such pathological condition is manifested in Parkinson's disease, the second most common neurological disorder in humans, which is characterized...
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2015) 8 (1): 57–63.
Published: 1 January 2015
...Víctor Fernández-Dueñas; Jaume J. Taura; Martin Cottet; Maricel Gómez-Soler; Marc López-Cano; Catherine Ledent; Masahiko Watanabe; Eric Trinquet; Jean-Philippe Pin; Rafael Luján; Thierry Durroux; Francisco Ciruela Parkinson’s disease (PD) is a dopaminergic-related pathology in which functioning...
Includes: Supplementary data