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Keywords: P-cadherin
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Journal Articles

Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation

Open Access
In collection:
Cancer , Drosophila as a Disease Model
Lídia Faria, Sara Canato, Tito T. Jesus, Margarida Gonçalves, Patrícia S. Guerreiro, Carla S. Lopes, Isabel Meireles, Eurico Morais-de-Sá, Joana Paredes, Florence Janody
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (2): dmm049652.
https://doi.org/10.1242/dmm.049652
Published: 21 February 2023
... progression. Among those, P-cadherin is highly enriched in basal-like breast carcinomas, playing a central role in cancer cell self-renewal, collective cell migration and invasion. To establish a clinically relevant platform for functional exploration of P-cadherin effectors in vivo , we generated a humanized...
View articletitled, Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation
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Includes: Supplementary data