... Huntingtin aggregation and reduced oxidative stress by activating auto-lysosomal functions. Further, overexpression of glycogen synthase in the brain rescues photoreceptor degeneration, improves locomotor deficits and increases fitness traits in this Huntington's disease model. We, thus, provide in vivo...

... Chuang; Ching-Hwa Sung; Anuradha Dhingra; Kathleen Boesze-Battaglia; Venkata R. M. Chavali; Joshua D. Rabinowitz; Claire H. Mitchell; Joshua L. Dunaief ABSTRACT Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration, the leading cause of blindness in older adults...

... localisation of a novel calcium binding protein, Iba1 . Mol. Brain Res. 57 , 1 - 9 . 10.1016/S0169-328X(98)00040-0 Keyse , S. M. , Applegate , L. A. , Tromvoukis , Y. and Tyrrell , R. M. ( 1990 ). Oxidant stress leads to transcriptional activation of the human heme oxygenase...

...Nicolas G. Clavere; Ali Alqallaf; Kerry A. Rostron; Andrew Parnell; Robert Mitchell; Ketan Patel; Samuel Y. Boateng ABSTRACT In the heart, ageing is associated with DNA damage, oxidative stress, fibrosis and activation of the activin signalling pathway, leading to cardiac dysfunction. The cardiac...

... be specifically detected in protein homogenates from injected zebrafish and in the frontal cortexes of C9FTD/ALS cases. Poly-GR expression further elevated MitoSOX levels in zebrafish embryos, indicating oxidative stress. Inhibition of reactive oxygen species using Trolox showed full suppression of poly-GR...

... of retinal rhabdomeres. Further, the dDBT mutant shows elevated oxidative stress and higher lipid peroxidation accumulation in the larval brain. Therefore, we conclude from in vivo evidence that the loss of dDBT results in oxidative brain damage that may lead to neuronal cell death and contribute to aspects...

... respiration of Fxn G127V cells upon alteration of fatty acid availability. Importantly, substitution of Fxn WT with Fxn G127V is compatible with life, and cellular proliferation defects can be rescued by mitigation of oxidative stress via hypoxia or induction of the NRF2 pathway. We propose Fxn G127V cells...

... strongly focus on myonecrosis and the associated inflammation and oxidative stress in DMD muscle, as the lack of dystrophin causes repeated bouts of myonecrosis, which are the key events that initiate the resultant severe dystropathology. We discuss the early events of intrinsic myonecrosis, along...

... microscopy to in cell infrared, we prove that overexpression of the frataxin gene affects the cellular metabolism. It also leads to a significant increase of oxidative stress and labile iron pool levels. These cellular alterations are similar to those observed when the gene is partly silenced, as occurs...

...-fluorodeoxyglucose uptake observed in HFD rats. The exposure of cardiac myoblasts (H9c2) to palmitic acid increased the rate of respiration, mainly due to an increase in the proton leak, glycolysis, oxidative stress, β-oxidation and reduced mitochondrial membrane potential. Inhibition of Gal-3 activity was unable...

... such as the accumulation of unfolded proteins, they would in turn cause oxidative stress in the form of increased production of reactive oxygen species. Various PD cell types are known to be subjected to a variety of cellular stresses ( Schapira et al., 2009 ; Schapira, 2011 ; Dias et al., 2013 ; Placido et al., 2015...

... protein expression of the DNA-damage-repair marker 8-oxoguanine-glycosylase (OGG1) in recuperated offspring. Recuperated animals also demonstrated an oxidative stress phenotype, with decreased citrate synthase activity, increased electron-transport-complex activities of complex I, complex II-III...

... cell death and activation of caspase-8 and -3 in the hypothalamus. Regulators of apoptosis such as FADD, Bcl-2, Bcl-xL and p53 were also increased, whereas p-IκB and c-FLIP L were decreased. This was accompanied by increased levels of Nox-4 and catalase, enzymes involved in oxidative stress. In summary...

... malformation in chick embryos. However, increased expression of Pax6 in chick embryos could rescue hyperglycemia-induced eye malformation. Hyperglycemia stimulated O-linked N -acetylglucosaminylation, which caused oxidative stress in chick embryos. Pax6 was found to be vulnerable to free radicals...

...Jennifer L. Philip; Md. Abdur Razzaque; Mei Han; Jinju Li; Tiju Theccanat; Xianyao Xu; Shahab A. Akhter ABSTRACT Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH...

...Stanislav Ott; Nikolas Dziadulewicz; Damian C. Crowther ABSTRACT Metals, including iron, are present at high concentrations in amyloid plaques in individuals with Alzheimer's disease, where they are also thought to be cofactors in generating oxidative stress and modulating amyloid formation...

... cells, RA induced the expression of Bmp2 , acted in concert with BMP2 to increase p53 expression, caspase activation and oxidative stress. This study provides direct evidence for modifying effects of the environment in a genetic mouse model carrying a predisposing mutation for HPE in the Twsg1 gene...