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Keywords: Oxidative stress
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Journal Articles
Dis Model Mech (2023) 16 (10): dmm050238.
Published: 19 October 2023
... Huntingtin aggregation and reduced oxidative stress by activating auto-lysosomal functions. Further, overexpression of glycogen synthase in the brain rescues photoreceptor degeneration, improves locomotor deficits and increases fitness traits in this Huntington's disease model. We, thus, provide in vivo...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (7): dmm050066.
Published: 25 July 2023
... Chuang; Ching-Hwa Sung; Anuradha Dhingra; Kathleen Boesze-Battaglia; Venkata R. M. Chavali; Joshua D. Rabinowitz; Claire H. Mitchell; Joshua L. Dunaief ABSTRACT Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration, the leading cause of blindness in older adults...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (7): dmm050226.
Published: 13 July 2023
..., at high levels it can be toxic to organs sensitive to oxidative stress, such as the eye ( Loh et al., 2009 ). There are several clinical examples of this in the eye. Ocular siderosis occurs when an iron-containing foreign body enters the eye, resulting in rapid photoreceptor and retinal pigment epithelium...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (5): dmm049424.
Published: 9 May 2022
...Nicolas G. Clavere; Ali Alqallaf; Kerry A. Rostron; Andrew Parnell; Robert Mitchell; Ketan Patel; Samuel Y. Boateng ABSTRACT In the heart, ageing is associated with DNA damage, oxidative stress, fibrosis and activation of the activin signalling pathway, leading to cardiac dysfunction. The cardiac...
Includes: Supplementary data
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Dis Model Mech (2020) 13 (8): dmm044750.
Published: 27 August 2020
... of retinal rhabdomeres. Further, the dDBT mutant shows elevated oxidative stress and higher lipid peroxidation accumulation in the larval brain. Therefore, we conclude from in vivo evidence that the loss of dDBT results in oxidative brain damage that may lead to neuronal cell death and contribute to aspects...
Includes: Supplementary data
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Dis Model Mech (2015) 8 (7): 657–667.
Published: 1 July 2015
...Stanislav Ott; Nikolas Dziadulewicz; Damian C. Crowther ABSTRACT Metals, including iron, are present at high concentrations in amyloid plaques in individuals with Alzheimer's disease, where they are also thought to be cofactors in generating oxidative stress and modulating amyloid formation...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (2): 139–146.
Published: 1 February 2015
... cells, RA induced the expression of Bmp2 , acted in concert with BMP2 to increase p53 expression, caspase activation and oxidative stress. This study provides direct evidence for modifying effects of the environment in a genetic mouse model carrying a predisposing mutation for HPE in the Twsg1 gene...
Includes: Supplementary data