1-2 of 2
Keywords: Osteoclast
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Autosomal recessive osteopetrosis: mechanisms and treatments

In collection:
Human Genetic Disease , Rare Disease Translational Research
Sara Penna, Anna Villa, Valentina Capo
Journal: Disease Models & Mechanisms
Dis Model Mech (2021) 14 (5): dmm048940.
https://doi.org/10.1242/dmm.048940
Published: 10 May 2021
...Sara Penna; Anna Villa; Valentina Capo ABSTRACT Autosomal recessive osteopetrosis (ARO) is a severe inherited bone disease characterized by defective osteoclast resorption or differentiation. Clinical manifestations include dense and brittle bones, anemia and progressive nerve compression, which...
View article titled, Autosomal recessive osteopetrosis: mechanisms and treatments
Open the PDF for Autosomal recessive osteopetrosis: mechanisms and treatments in another window
Journal Articles

Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice

Susan M. Motch Perrine, Meng Wu, Nicholas B. Stephens, Divya Kriti, Harm van Bakel, Ethylin Wang Jabs, Joan T. Richtsmeier
Journal: Disease Models & Mechanisms
Dis Model Mech (2019) 12 (5): dmm038513.
https://doi.org/10.1242/dmm.038513
Published: 30 May 2019
... revealed transcriptomic changes in mandibular bone at embryonic day 16.5 (E16.5), highlighting increased expression of genes related to osteoclast differentiation and dysregulated genes active in bone mineralization. Increased osteoclastic activity was corroborated by TRAP assay and in situ hybridization...
View article titled, Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice
Open the PDF for Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice in another window
Includes: Supplementary data