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Dis Model Mech (2021) 14 (2): dmm046359.
Published: 5 February 2021
... infiltrations and production of autoantibodies that resemble those observed in APECED patients, making the rat model a main research asset. In addition, ex vivo models of AIRE-dependent self-antigen expression in primary mTECs have been successfully set up. Thymus organoids based on pluripotent stem cell...
Shohei Yoshimoto, Junko Yoshizumi, Hiromasa Anzai, Koichiro Morishita, Kazuhiko Okamura, Akimitsu Hiraki, Shuichi Hashimoto
Dis Model Mech (2020) 13 (9): dmm045054.
Published: 28 September 2020
... epithelial stem/progenitor cells and tissue engineering approaches to induce organoids that mimic in vivo salivary glands. In this study, we clarified that inhibition of activin receptor-like kinase (Alk) signaling was essential for the induction of human salivary-gland-derived organoids, and demonstrated...
Includes: Supplementary data
Dis Model Mech (2017) 10 (2): 89–104.
Published: 1 February 2017
... by H. pylori , Helicobacter felis and Helicobacter suis in rodents and large animals. We also discuss the more recent development of gastric organoid cultures from murine and human gastric tissue, as well as from human pluripotent stem cells, and the outcomes of H. pylori infection in these systems...