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Keywords: Organoid
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Journal Articles
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2024) 17 (7): dmm050740.
Published: 22 July 2024
... due to the lack of a model system. Therefore, we developed human models of PCH2a using regionalized neural organoids. We generated induced pluripotent stem cell (iPSC) lines from three males with genetically confirmed PCH2a and subsequently differentiated cerebellar and neocortical organoids...
Includes: Supplementary data
Journal Articles
In collection:
Advanced in vitro models
Dis Model Mech (2021) 14 (2): dmm046359.
Published: 5 February 2021
... infiltrations and production of autoantibodies that resemble those observed in APECED patients, making the rat model a main research asset. In addition, ex vivo models of AIRE-dependent self-antigen expression in primary mTECs have been successfully set up. Thymus organoids based on pluripotent stem cell...
Journal Articles
In collection:
Advanced in vitro models
Dis Model Mech (2020) 13 (9): dmm045054.
Published: 28 September 2020
... epithelial stem/progenitor cells and tissue engineering approaches to induce organoids that mimic in vivo salivary glands. In this study, we clarified that inhibition of activin receptor-like kinase (Alk) signaling was essential for the induction of human salivary-gland-derived organoids, and demonstrated...
Includes: Supplementary data
Journal Articles
In collection:
Advanced in vitro models
Dis Model Mech (2017) 10 (2): 89–104.
Published: 1 February 2017
... by H. pylori , Helicobacter felis and Helicobacter suis in rodents and large animals. We also discuss the more recent development of gastric organoid cultures from murine and human gastric tissue, as well as from human pluripotent stem cells, and the outcomes of H. pylori infection in these systems...