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1-3 of 3
Keywords: Oligodendrocytes
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Journal Articles
In collection:
Neurodegenerative Disorders
,
Rare Disease Translational Research
,
Zebrafish as a Disease Model
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (8): dmm048925.
Published: 20 July 2021
... abnormalities are increasingly linked to white matter diseases. Complementing analyses of leukodystrophy patient material with animal models yields insight into the impact and therapeutic potential of microglia across diverse brain disorders. Microglia Myelination Leukodystrophy Oligodendrocytes...
Journal Articles
In collection:
Developmental Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2020) 13 (9): dmm046243.
Published: 25 September 2020
... of this model. Developmental disorders Brain development Milestones Adult behavior Oligodendrocytes National Institutes of Health NS105138 NS076503 HD098542 Down syndrome (DS) is caused by the triplication of chromosome 21 (HSA21) ( Lejeune et al., 1959...
Includes: Supplementary data
Journal Articles
Yulia Grishchuk, Karina A. Peña, Jessica Coblentz, Victoria E. King, Daniel M. Humphrey, Shirley L. Wang, Kirill I. Kiselyov, Susan A. Slaugenhaupt
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (12): 1591–1601.
Published: 1 December 2015
... and a hypoplastic corpus callosum are the major hallmarks of MLIV brain pathology. Here, we report that loss of TRPML1 in mice results in developmental aberrations of brain myelination as a result of deficient maturation and loss of oligodendrocytes. Defective myelination is evident in Mcoln1 −/− mice at postnatal...
Includes: Supplementary data
