... nephropathy (DN) shows key features of human DN, activation of the PI3K/Akt pathway and the protective role of metformin, which highlight the potential of this model for therapeutic discovery. Obesity Type 2 diabetes Diabetic nephropathy Zebrafish Proteinuria Glomerular hypertrophy Japan...

... well-established and emerging Xiphophorus fishes and their interspecies hybrids can be used for studying human diseases, to highlight research opportunities enabled by these unique models. Cancer Emerging models Epistasis Expression dysregulation Hybrid incompatibility Obesity...

...Zhasmine Mirzoyan; Alice Valenza; Sheri Zola; Carola Bonfanti; Lorenzo Arnaboldi; Nicholas Ferrari; John Pollard; Valeria Lupi; Matteo Cassinelli; Matteo Frattaroli; Mehtap Sahin; Maria Enrica Pasini; Paola Bellosta ABSTRACT Obesity is associated with various metabolic disorders, such as insulin...

...Emily Montal; Dianne Lumaquin; Yilun Ma; Shruthy Suresh; Richard M. White ABSTRACT Obesity is a rising concern and associated with an increase in numerous cancers, often in a sex-specific manner. Preclinical models are needed to deconvolute the intersection between obesity, sex and melanoma. Here...

...Sarah Talley; Raiza Bonomo; Chaitanya Gavini; Jomana Hatahet; Emily Gornick; Tyler Cook; Byeong Jae Chun; Pete Kekenes-Huskey; Gregory Aubert; Edward Campbell; Virginie Mansuy-Aubert ABSTRACT Obesity is an epidemic, and it is characterized by a state of low-grade systemic inflammation. A key...

...Sol Díaz de León-Guerrero; Jonathan Salazar-León; Karla F. Meza-Sosa; David Valle-Garcia; Diana Aguilar-León; Gustavo Pedraza-Alva; Leonor Pérez-Martínez ABSTRACT Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose...

... and obesity, multimorbidity is a rapidly growing clinical issue in the context of cancer. Cancer is also genetically heterogeneous, with a tumour's unique profile determining its incidence of metastasis, degree of cachexia and response to therapeutics. These complexities of human cancer are difficult...

... reported PN sex dimorphism in obese leptin-deficient ob / ob mice. This genetic model is inherently limited, however, owing to leptin's role in metabolism. Therefore, the current study goal was to examine PN and insulin resistance in male and female C57BL6/J mice fed a high-fat diet (HFD), an established...

...Cara E. Wogsland; Hilde E. Lien; Line Pedersen; Pahul Hanjra; Sturla M. Grondal; Rolf A. Brekken; James B. Lorens; Nils Halberg ABSTRACT Obesity is a disease characterized by chronic low-grade systemic inflammation and has been causally linked to the development of 13 cancer types. Several studies...

... of tight junction molecules, microbiota diversity and short-chain fatty acids. Fatty liver Autonomic neuron Obesity Diet Hormone Japanese Society for the Promotion of Sciences 18K19537 Niigata University http://dx.doi.org/10.13039/100012833 The number of non...

... Fatty liver Obesity Metabolic syndrome NAFLD Insulin resistance Fatty liver (FL) represents an abnormal metabolic condition of excess intrahepatic fat (>5.5% w/w liver fat fraction), which is also referred to as hepatic steatosis. FL and its association with chronic liver disease...

... decreased transcriptional activity when coexpressed with SIM1. These findings establish a requirement for ARNT2-dependent genes in the maintenance of the homeostatic feeding response, necessary for prevention of obesity and obesity-related diseases. Age- and sex-matched mice were randomly allocated...

...Phillipe D. O'Brien; Lucy M. Hinder; Amy E. Rumora; John M. Hayes; Jacqueline R. Dauch; Carey Backus; Faye E. Mendelson; Eva L. Feldman ABSTRACT Peripheral neuropathy (neuropathy) is a common complication of obesity and type 2 diabetes in children and adolescents. To model this complication in mice...

...Elise L. Donovan; Erika Barboza Prado Lopes; Albert Batushansky; Mike Kinter; Timothy M. Griffin ABSTRACT Obesity is one of the most significant risk factors for knee osteoarthritis. However, therapeutic strategies to prevent or treat obesity-associated osteoarthritis are limited because...

...Gema Marín-Royo; Isabel Gallardo; Ernesto Martínez-Martínez; Beatriz Gutiérrez; Raquel Jurado-López; Natalia López-Andrés; Josué Gutiérrez-Tenorio; Eduardo Rial; Marı́a Visitación Bartolomé; María Luisa Nieto; Victoria Cachofeiro ABSTRACT Obesity is accompanied by metabolic alterations...

..., including central obesity, fatty liver and waist-to-hip ratio. LYPLAL1 is also known to be upregulated in the adipose tissue of obese patients. However, the physiological role of LYPLAL1 is not understood. To investigate the function of Lyplal1 in vivo we investigated the phenotype of the Lyplal1 tm1a(KOMP...

...Michael J. Haley; Graham Mullard; Katherine A. Hollywood; Garth J. Cooper; Warwick B. Dunn; Catherine B. Lawrence ABSTRACT Obesity is an independent risk factor for stroke, although several clinical studies have reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery...

...Katharina Timper; Jens C. Brüning ABSTRACT The ‘obesity epidemic’ represents a major global socioeconomic burden that urgently calls for a better understanding of the underlying causes of increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus...

...Lucy M. Hinder; Phillipe D. O'Brien; John M. Hayes; Carey Backus; Andrew P. Solway; Catrina Sims-Robinson; Eva L. Feldman ABSTRACT Patients with metabolic syndrome, which is defined as obesity, dyslipidemia, hypertension and impaired glucose tolerance (IGT), can develop the same macro...

...Perry Barrett; Julian G. Mercer; Peter J. Morgan ABSTRACT A multi-dimensional strategy to tackle the global obesity epidemic requires an in-depth understanding of the mechanisms that underlie this complex condition. Much of the current mechanistic knowledge has arisen from preclinical research...