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Keywords: OPA1
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Journal Articles
Jiří Funda, Josep A. Villena, Kristina Bardova, Katerina Adamcova, Illaria Irodenko, Pavel Flachs, Ivana Jedlickova, Eliska Haasova, Martin Rossmeisl, Jan Kopecky, Petra Janovska
Journal:
Disease Models & Mechanisms
Dis Model Mech (2022) 15 (4): dmm049223.
Published: 25 April 2022
... (1) dynamin-related protein 1 (DRP1; officially known as DNM1L), a GTPase regulating mitochondrial fission ( Mishra and Chan, 2016 ), (2) mitofusin 1 and 2 (MFN1, MFN2), proteins involved in fusion of outer mitochondrial membranes, and (3) optic atrophy 1 protein (OPA1), which regulates fusion...
Includes: Supplementary data
Journal Articles
In collection:
Drug Discovery
Thomas Delerue, Déborah Tribouillard-Tanvier, Marlène Daloyau, Farnoosh Khosrobakhsh, Laurent Jean Emorine, Gaëlle Friocourt, Pascale Belenguer, Marc Blondel, Laetitia Arnauné-Pelloquin
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (2): dmm036558.
Published: 7 February 2019
..., which are conserved from yeast to human, are essential, and their disturbances are associated with severe human disorders, including neurodegenerative diseases. For example, mutations in OPA1 , which encodes a conserved factor essential for mitochondrial fusion, lead to optic atrophy 1...
Includes: Supplementary data
