...Brian Chipman Belyea; Fang Xu; Maria Luisa Soledad Sequeira-Lopez; Roberto Ariel Gomez ABSTRACT Conditional deletion of RBP-J , the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence...

... is altered even in young mdx mice, with significant reductions in the abundance of non-committed (Pax7 + and Myf5 − ) satellite cells. Using a Notch-reporter mouse, we found that the mdx satellite cells have reduced activation of Notch signaling, which has been shown to be necessary to maintain satellite...