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Keywords: Neutrophil
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Journal Articles
Journal Articles
Dis Model Mech (2023) 16 (6): dmm049966.
Published: 3 May 2023
... signalling in raising an appropriate immune response are underappreciated, representing overlooked potential drug targets. This is especially true in neutrophils, a difficult cell type to study ex vivo owing to a short lifespan, dogmatically seen as being highly pro-inflammatory. Here, we have generated...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (3): dmm049841.
Published: 13 March 2023
... mutations of the PIK3CD gene that encodes the PI3 kinase delta (PI3Kδ) catalytic subunit. Despite the importance of innate immunity defects in bronchiectasis, there has been limited investigation of neutrophils or macrophages in APDS1 patients or mouse models. Zebrafish embryos provide an ideal system...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2023) 16 (2): dmm049715.
Published: 30 January 2023
...Maaike Allers; Petra A. Bakker; Jelmer Hoeksma; Herman P. Spaink; Jeroen den Hertog ABSTRACT PTPN6 encodes SHP1, a protein tyrosine phosphatase with an essential role in immune cell function. SHP1 mutations are associated with neutrophilic dermatoses and emphysema in humans, which resembles...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Dis Model Mech (2018) 11 (2): dmm032151.
Published: 26 February 2018
... of Sept15-depleted larvae during infection revealed a failure of neutrophils to control infection. Susceptibility of septin morphants (see Glossary, Box 1 ) to infection is strictly dependent on the Shigella T3SS, as infection with T3SS-deficient S. flexneri is equally controlled by control or Sept15...
Journal Articles
Journal Articles
Dis Model Mech (2014) 7 (9): 1069–1081.
Published: 1 September 2014
... new uses for existing drugs – is emerging as an alternative strategy to traditional drug design that promises an improved risk-reward trade-off. Using a zebrafish in vivo neutrophil migration assay, we undertook a drug repositioning screen to identify unknown anti-inflammatory activities for known...
Includes: Supplementary data
Journal Articles