...Anna E. Eberwein; Swarat S. Kulkarni; Emma Rushton; Kendal Broadie ABSTRACT The lipid storage disease Niemann Pick type C (NPC) causes neurodegeneration owing primarily to loss of NPC1. Here, we employed a Drosophila model to test links between glycosphingolipids, neurotransmission...

... loss accompanied by defects in both structural architecture and functional neurotransmission. NMJ synaptogenesis is driven by intercellular signals that traverse an extracellular synaptomatrix and are co-regulated by glycosylation and matrix metalloproteinases (MMPs). Specifically, trans-synaptic...

...-translocation from the ER lumen into the cytosol . Nature   429 , 841 – 847 . ALS ER stress Chaperone Neurotransmission TorsinA Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the upper and lower motor neurons; it provokes muscle weakness that initiates...