...Andrew H. Miller; Mary C. Halloran ABSTRACT Neurofibromatosis type 1 (NF1) is an autosomal-dominant neurogenetic disorder caused by mutations in the gene neurofibromin 1 ( NF1 ). NF1 predisposes individuals to a variety of symptoms, including peripheral nerve tumors, brain tumors and cognitive...

.... With the cloning of the NF1 gene and the recognition that the encoded protein, neurofibromin, largely functions as a negative regulator of RAS activity, attention has mainly focused on RAS and canonical RAS effector pathway signaling relevant to disease pathogenesis and treatment. However, as neurofibromin...