... in a broader range of age-related neurodegenerative diseases, and summarize the biological factors linking APOE to sex hormones, drawing on supportive findings from rodent models to identify major mechanistic themes underlying the exacerbation of LOAD-associated neurodegeneration and pathology in the female...

... mediator of cerebellar dysfunction and ataxia, and indicate a potential therapeutic target for early intervention of Friedreich ataxia. Cerebellum Friedreich ataxia Mitochondrial biogenesis Respiratory chain complex Neurodegenerative diseases Friedreich ataxia (FRDA), the most common...

...Anne-Laure Bougé; Marie-Laure Parmentier ABSTRACT In neurodegenerative diseases such as Alzheimer's disease (AD), cell cycle defects and associated aneuploidy have been described. However, the importance of these defects in the physiopathology of AD and the underlying mechanistic processes...