...Beatriz Fernández-Santos; Marta Reyes-Corral; José Manuel Caro-Vega; Miguel Lao-Pérez; Claudia Vallejo-Grijalba; Cristina Mesa-Cruz; Francisco J. Morón; Patricia Ybot-González ABSTRACT Neural tube defects (NTDs) are the second most common cause of congenital malformations and are often studied...

.... Summary: We identify a dual mechanism of spina bifida in Zic2 mutant mice – a possible paradigm for multifactorial human defects. BMP overactivation prevents neuroepithelial bending, whereas RhoA overactivation causes actomyosin accumulation. Embryo Neurulation Neural tube defects Actomyosin...

...Sonia Sudiwala; Alexandra Palmer; Valentina Massa; Alan J. Burns; Louisa P. E. Dunlevy; Sandra C. P. de Castro; Dawn Savery; Kit-Yi Leung; Andrew J. Copp; Nicholas D. E. Greene ABSTRACT Neural tube defects (NTDs), including spina bifida and anencephaly, are among the most common birth defects...

... cytoskeleton and development of lens three-dimensional architecture . Dev. Biol.   324 , 161 – 176 . Chen   B. , Mao   H. H. , Chen   L. , Zhang   F. L. , Li   K. , Xue   Z. F. ( 2013 ). Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from...

...Jennifer N. Murdoch; Christine Damrau; Anju Paudyal; Debora Bogani; Sara Wells; Nicholas D. E. Greene; Philip Stanier; Andrew J. Copp Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events...