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Keywords: NSG mice
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Journal Articles

Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγ null mice reconstituted with human peripheral blood mononuclear cells

In collection:
Drug Discovery
Henrika Jodeleit, Paula Winkelmann, Janina Caesar, Sebastian Sterz, Lesca M. Holdt, Florian Beigel, Johannes Stallhofer, Simone Breiteneicher, Eckart Bartnik, Thomas Leeuw, Matthias Siebeck, Roswitha Gropp
Journal: Disease Models & Mechanisms
Dis Model Mech (2021) 14 (1): dmm046995.
https://doi.org/10.1242/dmm.046995
Published: 21 January 2021
... that the original work is properly attributed. Summary: The combination of patient profiling and testing in a NOD/Scid IL2Rγ null mouse model of ulcerative colitis (UC) validates oxelumab as a potential therapeutic in UC. NOD/Scid IL2Rγ null NSG mice Ulcerative colitis Anti-CD252 antibodies...
View article titled, Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγ null mice reconstituted with human peripheral blood mononuclear cells
Open the PDF for Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγ null mice reconstituted with human peripheral blood mononuclear cells in another window
Includes: Supplementary data
Journal Articles

A mouse model for ulcerative colitis based on NOD- scid IL2R γ null mice reconstituted with peripheral blood mononuclear cells from affected individuals

Pia Palamides, Henrika Jodeleit, Michael Föhlinger, Florian Beigel, Nadja Herbach, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp
Journal: Disease Models & Mechanisms
Dis Model Mech (2016) 9 (9): 985–997.
https://doi.org/10.1242/dmm.025452
Published: 1 September 2016
... attributed. Summary: The phenotype and colitis-like symptoms induced in NSG mice reconstituted with PBMCs derived from ulcerative-colitis-affected donors reflect the human disease. Ulcerative colitis NSG mice Infliximab Pitrakinra Bundesministerium für Bildung und Forschung...
View article titled, A mouse model for ulcerative colitis based on NOD- scid IL2R γ null mice reconstituted with peripheral blood mononuclear cells from affected individuals
Open the PDF for A mouse model for ulcerative colitis based on NOD- scid IL2R γ null mice reconstituted with peripheral blood mononuclear cells from affected individuals in another window
Includes: Supplementary data