1-5 of 5
Keywords: N-ethyl-N-nitrosourea
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Dis Model Mech (2023) 16 (9): dmm050043.
Published: 8 September 2023
... tract, we used a forward genetic screen of N-ethyl-N-nitrosourea (ENU) mutagenized mice and determined that a mutation in Degs2 confers hypersensitivity to dextran sodium sulfate (DSS). In DEGS2-deficient mice, the intestinal epithelium fails to proliferate in response to damage from DSS. Moreover...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2021) 14 (6): dmm048901.
Published: 18 June 2021
... twice or more in the homozygous state. Of the 1275 pedigrees screened, 7.4% presented with severe spine deformity developing in multiple mice, and of these, meiotic mapping implicated N-ethyl-N-nitrosourea alleles in 21% of pedigrees. Our study provides proof of concept that saturation mutagenesis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (12): dmm035451.
Published: 18 December 2018
... mice derived from N -ethyl- N -nitrosourea (ENU)-mutagenized great-grandsires for weight abnormalities. Among 17 elevated body weight phenotypes identified and mapped, one strongly correlated with an induced missense mutation in Arnt2 using a semidominant model of inheritance. Causation was confirmed...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (9): dmm035923.
Published: 27 September 2018
... of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause...
Journal Articles