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Keywords: N-ethyl-N-nitrosourea
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Journal Articles
Ran Song, Aaron Fond, Xiaohong Li, Miao Tang, Xiaoming Zhan, Ruth Gordillo, Eva Marie Y. Moresco, Bruce Beutler, Emre E. Turer
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (9): dmm050043.
Published: 8 September 2023
... tract, we used a forward genetic screen of N-ethyl-N-nitrosourea (ENU) mutagenized mice and determined that a mutation in Degs2 confers hypersensitivity to dextran sodium sulfate (DSS). In DEGS2-deficient mice, the intestinal epithelium fails to proliferate in response to damage from DSS. Moreover...
Includes: Supplementary data
Journal Articles
In collection:
Developmental Disorders
Jonathan J. Rios, Kristin Denton, Hao Yu, Kandamurugu Manickam, Shannon Garner, Jamie Russell, Sara Ludwig, Jill A. Rosenfeld, Pengfei Liu, Jake Munch, Daniel J. Sucato, Bruce Beutler, Carol A. Wise
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (6): dmm048901.
Published: 18 June 2021
... twice or more in the homozygous state. Of the 1275 pedigrees screened, 7.4% presented with severe spine deformity developing in multiple mice, and of these, meiotic mapping implicated N-ethyl-N-nitrosourea alleles in 21% of pedigrees. Our study provides proof of concept that saturation mutagenesis...
Includes: Supplementary data
Journal Articles
Emre E. Turer, Miguel San Miguel, Kuan-wen Wang, William McAlpine, Feiya Ou, Xiaohong Li, Miao Tang, Zhao Zang, Jianhui Wang, Braden Hayse, Bret Evers, Xiaoming Zhan, Jamie Russell, Bruce Beutler
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (12): dmm035451.
Published: 18 December 2018
... mice derived from N -ethyl- N -nitrosourea (ENU)-mutagenized great-grandsires for weight abnormalities. Among 17 elevated body weight phenotypes identified and mapped, one strongly correlated with an induced missense mutation in Arnt2 using a semidominant model of inheritance. Causation was confirmed...
Includes: Supplementary data
Journal Articles
William McAlpine, Kuan-wen Wang, Jin Huk Choi, Miguel San Miguel, Sarah Grace McAlpine, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Xiaoming Zhan, Mihwa Choi, Tao Wang, Chun Hui Bu, Anne R. Murray, Eva Marie Y. Moresco, Emre E. Turer, Bruce Beutler
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (9): dmm035923.
Published: 27 September 2018
... of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause...
Journal Articles
Ashlee J. Conway, Fiona C. Brown, Elinor J. Hortle, Gaetan Burgio, Simon J. Foote, Craig J. Morton, Stephen M. Jane, David J. Curtis
Journal:
Disease Models & Mechanisms
Dis Model Mech (2018) 11 (5): dmm034678.
Published: 21 May 2018
...Ashlee J. Conway; Fiona C. Brown; Elinor J. Hortle; Gaetan Burgio; Simon J. Foote; Craig J. Morton; Stephen M. Jane; David J. Curtis ABSTRACT In this study, we performed a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen in mice to identify novel genes or alleles that regulate...