... . With aging, the muscles of the mutant flies began showing abnormal distribution of actin and myosin in muscles, but without a change in actin and myosin protein levels. This age-related phenotype could not be rescued by eEF1α1 overexpression. These findings support an unconventional role of Drosophila eEF1α2...

...Joshua Abrams; Zev Einhorn; Christoph Seiler; Alan B. Zong; H. Lee Sweeney; Michael Pack ABSTRACT Smooth muscle contraction is controlled by the regulated activity of the myosin heavy chain ATPase (Myh11). Myh11 mutations have diverse effects in the cardiovascular, digestive and genitourinary...

...Karen A. Newell-Litwa; Rick Horwitz; Marcelo L. Lamers ABSTRACT The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell morphology, with a role in several essential cellular processes, including cell migration and post-synaptic dendritic spine plasticity in neurons...

...Jing Bi; Robert T. Carroll; Michael L. James; Jessica L. Ouderkirk; Mira Krendel; Vladimir Sirotkin ABSTRACT Point mutations in the human MYO1E gene, encoding class I myosin Myo1e, are associated with focal segmental glomerulosclerosis (FSGS), a primary kidney disorder that leads to end-stage...