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Keywords: Myelin
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Journal Articles

Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish

In collection:
Drug Discovery , Zebrafish as a Disease Model
David Zada, Adi Tovin, Tali Lerer-Goldshtein, Lior Appelbaum
Journal: Disease Models & Mechanisms
Dis Model Mech (2016) 9 (11): 1339–1348.
https://doi.org/10.1242/dmm.027227
Published: 1 November 2016
... and BBB-targeted gene therapy that can enhance myelination in AHDS and possibly in other TH-dependent brain disorders. The quantification of genetic markers for glial cells in the entire body hinted for hypomyelination in mct8 −/− zebrafish. However, live imaging of specific tissues in single-cell...
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Journal Articles

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

Marina R. Carpinelli, Anne K. Voss, Michael G. Manning, Ashwyn A. Perera, Anne A. Cooray, Benjamin T. Kile, Rachel A. Burt
Journal: Disease Models & Mechanisms
Dis Model Mech (2014) 7 (6): 649–657.
https://doi.org/10.1242/dmm.014605
Published: 1 June 2014
... and deafness . Neurology   60 , 1702 – 1704 . Ito   T. , Tokuriki   M. , Shibamori   Y. , Saito   T. , Nojyo   Y. ( 2004 ). Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) rat . Hear. Res.   191 , 119 – 124 . Kanzaki   J...
View articletitled, A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination
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Includes: Supplementary data