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Keywords: Mycobacterium tuberculosis
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Journal Articles

An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor

Open Access
In collection:
Drug Discovery , Infectious disease biology , Zebrafish as a Disease Model
Eva Habjan, Vien Q. T. Ho, James Gallant, Gunny van Stempvoort, Kin Ki Jim, Coen Kuijl, Daan P. Geerke, Wilbert Bitter, Alexander Speer
Journal: Disease Models & Mechanisms
Dis Model Mech (2021) 14 (12): dmm049145.
https://doi.org/10.1242/dmm.049145
Published: 23 December 2021
... Mycobacterium tuberculosis isolates. In this study, we exploited the medium-throughput capabilities of the zebrafish embryo infection model with Mycobacterium marinum as a surrogate for M. tuberculosis . Using a representative set of clinically established drugs, we demonstrate that this model could...
View articletitled, An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor
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Includes: Supplementary data
Journal Articles

FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

Open Access
In collection:
Infectious disease biology
Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, III, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann
Journal: Disease Models & Mechanisms
Dis Model Mech (2020) 13 (3): dmm041954.
https://doi.org/10.1242/dmm.041954
Published: 30 March 2020
... immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis -infected animals present elevated levels of Ldha and lactate. Such alterations in the metabolic milieu could influence the outcome of host- M. tuberculosis interactions. Given the central role of LDHA for tumorigenicity, targeting...
View articletitled, FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity
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Includes: Supplementary data
Journal Articles

Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice

Open Access
Muhammad K. K. Niazi, Nimit Dhulekar, Diane Schmidt, Samuel Major, Rachel Cooper, Claudia Abeijon, Daniel M. Gatti, Igor Kramnik, Bulent Yener, Metin Gurcan, Gillian Beamer
Journal: Disease Models & Mechanisms
Dis Model Mech (2015) 8 (9): 1141–1153.
https://doi.org/10.1242/dmm.020867
Published: 1 September 2015
...Muhammad K. K. Niazi; Nimit Dhulekar; Diane Schmidt; Samuel Major; Rachel Cooper; Claudia Abeijon; Daniel M. Gatti; Igor Kramnik; Bulent Yener; Metin Gurcan; Gillian Beamer ABSTRACT Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible humans . Here, we infected...
View articletitled, Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice
Open the PDF for Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice in another window
Includes: Supplementary data