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Keywords: Multi-omics analysis
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Journal Articles

Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

Open Access
In collection:
Neuromuscular Disease
Sai S. Pradhan, Sai M. Thota, Saiswaroop Rajaratnam, Sai K. S. Bhagavatham, Sujith K. Pulukool, Sriram Rathnakumar, Kanikaram S. Phalguna, Rajesh B. Dandamudi, Ashish Pargaonkar, Prasanth Joseph, E. V. Joshy, Venketesh Sivaramakrishnan
Journal: Disease Models & Mechanisms
Dis Model Mech (2022) 15 (10): dmm049492.
https://doi.org/10.1242/dmm.049492
Published: 31 October 2022
... aggregation. Metabolomics analysis of HD patients and of a yeast model of HD was, therefore, carried out. Our analysis showed a considerable overlap of deregulated metabolic pathways. Further, the multi-omics analysis showed deregulated pathways common in human, mice and yeast model systems, and those...
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Includes: Supplementary data