1-20 of 23
Keywords: Mouse models
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Dis Model Mech (2021) 14 (5): dmm047498.
Published: 04 May 2021
... constitutive/conditional Hnf1b ablation leads to more severe phenotypes. We generated a novel mouse model carrying an identified human mutation at the intron-2 splice donor site. Unlike heterozygous mice previously characterized, mice heterozygous for the splicing mutation exhibited decreased HNF1B protein...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (11): dmm046565.
Published: 18 November 2020
...-reperfusion are common models for studying myocardial infarction. Here, we summarise the differences between them and outline the strengths of each in addressing distinct questions related to the human condition. Myocardial infarction Mouse models LAD ligation Ischaemia-reperfusion...
Journal Articles
Dis Model Mech (2020) 13 (10): dmm047035.
Published: 30 October 2020
...: The study describes a single-cell transcriptomic atlas of the mouse uterus and shows that PAX8 + cells are responsible for long-term maintenance of endometrial epithelium and might represent the cell of origin of serous endometrial carcinoma. Endometrial cancer Mouse models Single-cell...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (3): dmm042614.
Published: 13 March 2020
... heterogeneous in the timing of clinical presentation and is associated with a wide spectrum of causative NPC1 mutations. To study the genetic architecture of NPC1, we have generated a new NPC1 mouse model, Npc1 em1Pav . Npc1 em1Pav/em1Pav mutants showed notably reduced NPC1 protein compared to controls and...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm043562.
Published: 21 February 2020
... has played a key role in our understanding of the molecular mechanisms underlying MD pathogenesis. This has enabled the development of therapeutic strategies. Owing to advancements in genetic engineering, a wide variety of mouse models are available for the majority of MDs. Here, we summarize the...
Journal Articles
Dis Model Mech (2019) 12 (12): dmm041004.
Published: 17 December 2019
...; Scott Kopetz; Dipen Maru ABSTRACT Mouse models of gastroesophageal junction (GEJ) cancer strive to recapitulate the intratumoral heterogeneity and cellular crosstalk within patient tumors to improve clinical translation. GEJ cancers remain a therapeutic challenge due to the lack of a reliable mouse...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm038224.
Published: 07 May 2019
... campaigns provide data for thousands of mutant mouse genes, yielding key information for understanding rare human diseases and for developing novel drug therapies. Knockout mice Mouse models Phenotyping Phenomics Translational medicine Understanding gene function can explain the disease...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (12): dmm037374.
Published: 18 December 2018
... DIO-STZ mice at all time points despite significantly higher fasting glucose levels in the DIO-STZ mice. These mouse models provide critical tools to better understand the underlying pathogenesis of prediabetic and diabetic neuropathy from youth to adulthood, and support the idea that hyperglycemia...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (10): dmm035360.
Published: 01 October 2018
... environments affect phenotypes is critical for the development of models of human disease. Husbandry Diet Environment Stress Mouse models Human “ Little boxes, little boxes, little boxes all the same ” – Pete Seeger's cover of Malvina Reynolds’ ‘ Little Boxes ’ 1 One question...
Journal Articles
Dis Model Mech (2018) 11 (6): dmm035774.
Published: 13 June 2018
.... Sui and colleagues have now added a dystrophic rabbit model to this range using CRISPR/Cas9 to disrupt exon 51 of DMD . Rabbits have the advantage of being easier to breed and less costly than dog or pig models, but having clear clinical signs, in contrast to many mouse models. There appears to be an...
Journal Articles
Dis Model Mech (2018) 11 (5): dmm031724.
Published: 18 May 2018
... models. Summary: This Review examines the use of functional magnetic resonance imaging for studying Alzheimer's disease in animal models, and addresses important considerations concerning model choice, anesthetic use and application of stimuli. Alzheimer's disease fMRI Mouse models...
Journal Articles
Dis Model Mech (2017) 10 (9): 1061–1074.
Published: 01 September 2017
... tumor is determined by genetic and epigenetic changes within the cancer cells as well as contributions from cells in the tumor microenvironment. Mouse models have proven to be an important tool for unraveling the complex interactions involved in the metastatic cascade and delineating its many stages...
Journal Articles
Dis Model Mech (2017) 10 (4): 359–371.
Published: 01 April 2017
...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: This Review provides a summary of the many varied uses of mouse models in breast cancer research focusing on their strengths...
Journal Articles
Dis Model Mech (2017) 10 (2): 119–126.
Published: 01 February 2017
...: Heterozygous expression of the X-linked gene Atrx in the mouse brain causes deficits in spatial, contextual fear and object recognition memory. ATRX Central nervous system Mouse models Neurobehaviour All data were analysed using GraphPad Prism software or SPSS, with Student's t -test...
Journal Articles
Dis Model Mech (2016) 9 (9): 941–952.
Published: 01 September 2016
... an effective inhibitor of ALK with greater activity towards ALK neuroblastoma mutants. In contrast to crizotinib, single agent administration of PF-06463922 caused dramatic tumor inhibition in both subcutaneous and orthotopic xenografts as well as a mouse model of high-risk neuroblastoma driven by Th...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (11): 1361–1373.
Published: 01 November 2015
... occurrence that coincides with upregulation of markers for human colorectal cancer progression. Colorectal cancer Mouse models GpA33 Inflammation * These authors contributed equally to this work ‡ Authors for correspondence ( michael.buchert@onjcri.org.au ; klaus-peter.janssen...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (9): 1155–1166.
Published: 01 September 2015
...Minsi Zhang; David G. Kirsch ABSTRACT Novel genetically engineered mouse models using the Cre- loxP or the Flp- FRT systems have generated useful reagents to manipulate the mouse genome in a temporally-regulated and tissue-specific manner. By incorporating a constitutive Cre driver line into a...
Journal Articles
Dis Model Mech (2015) 8 (8): 867–875.
Published: 01 August 2015
... promote development of distant metastases in a mouse model of primary soft tissue sarcoma (STS). In this study, we identified miRNAs that are differentially downregulated in metastatic STS in both human and mouse, and investigated the role of these miRNAs in metastasis. miRNA- TaqMan PCR arrays showed a...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (7): 743–753.
Published: 01 July 2015
... or pathways that are sequentially perturbed at earlier phases of disease progression. We have therefore explored the option of utilizing mouse models to understand in a systematic and longitudinal manner the molecular pathways that are progressively deregulated by various etiological factors in...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (6): 591–602.
Published: 01 June 2015
... with respect to bacterial load, cellular composition and degree of immunopathology following low-dose aerosol infection with Mycobacterium tuberculosis . C3HeB/FeJ Tuberculosis Mouse models Chemotherapy Neutrophil References Alemán , M. , de la Barrera , S. , Schierloh...