... dysregulation observed in the disease and potentially perturbed gene expression in neighbouring neurons. Microglia MicroRNA TDP-43 Amyotrophic lateral sclerosis Motor neuron disease University of Sussex http://dx.doi.org/10.13039/501100000838 Motor Neurone Disease Association...

... attributed. Summary: Recently approved gene-targeting therapies for spinal muscular atrophy are leading to milder and more variable phenotypes in patients. Here, we discuss requirements for next-generation disease models to incorporate these therapeutic developments. Gene therapy Motor neuron...

... lateral sclerosis (ALS), probably as a neuroprotective endogenous mechanism. Nurr1 might represent a promising target for ALS therapy. ALS SOD1-G93A mice Motor neuron disease Neuroinflammation Nurr1 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects both...

... provided that the original work is properly attributed. Motor neuron disease Amyotrophic lateral sclerosis Excitotoxicity Lower motor neuron Excitotoxin exposure Amyotrophic lateral sclerosis (ALS) is the predominant form of motor neuron disease (MND) and is one of the most devastating...