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Keywords: Mitophagy
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Journal Articles
Dis Model Mech (2021) 14 (6): dmm048912.
Published: 11 June 2021
... diseases Mitochondrial fusion and fission Mitochondrial unfolded protein response Mitophagy mtDNA heteroplasmy and inheritance mtDNA-mediated innate immune response The word ‘mitochondria’ stems from the Greek words ‘mitos’ for ‘thread’ and ‘chondro’ for ‘grain’. It was coined...
Journal Articles
Dis Model Mech (2019) 12 (6): dmm039396.
Published: 27 June 2019
..., presumably owing to a loss of inhibitory control, whereas genetic models primarily result in a progressive loss of heat perception, reflecting sensory fiber neuropathies. At the molecular level, neither α-synuclein deposits alone nor failure of mitophagy alone appear to be strong enough to result in axonal...
Journal Articles
Dis Model Mech (2017) 10 (9): 1075–1087.
Published: 1 September 2017
... Mitochondria Fusion-fission Transport Mitophagy A reduction in mitochondrial size is a requirement for mitochondrial clearance. This view is supported by findings showing that elongated mitochondrial phenotypes prevent mitophagy as a result of protein kinase A (PKA)-mediated inhibition of Drp1, even...