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Keywords: Mitochondrial permeability transition pore formation
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Journal Articles
Nadia Sachewsky, Jessica Hunt, Michael J. Cooke, Ashkan Azimi, Taraneh Zarin, Carween Miu, Molly S. Shoichet, Cindi M. Morshead
Journal:
Disease Models & Mechanisms
Dis Model Mech (2014) 7 (8): 953–961.
Published: 1 August 2014
... as drugs that inhibit cyclophilin A-mediated activation of calcineurin. To evaluate the calcineurin-independent pathway, we utilized NIM811, a non-immunosuppressive CsA analog that functions independently of calcineurin by blocking mitochondrial permeability transition pore formation. We found that only...