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Keywords: Mitochondria
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Journal Articles
Dis Model Mech (2023) 16 (10): dmm050114.
Published: 9 October 2023
... induction in response to FXN loss in this model remain to be elucidated. A putative mechanism could involve defective FXN maturation due to the FXN G127V mutation, which could be a source of proteotoxic stress in mitochondria. However, recent evidence indicates that residual G127V FXN retained its...
Includes: Supplementary data
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Dis Model Mech (2023) 16 (1): dmm049727.
Published: 25 January 2023
... metabolism in Parkinson's disease models. Drosophila Stem cell research PINK1 Mitochondria Metabolism Parkinson's disease AstraZeneca http://dx.doi.org/10.13039/100004325 Medical Research Council http://dx.doi.org/10.13039/501100000265 RG94521 University...
Includes: Supplementary data
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Dis Model Mech (2022) 15 (12): dmm049871.
Published: 1 December 2022
... to be interconnected with mitochondria. These data suggest the existence of a fundamental process whereby healthy mammalian photoreceptors release mistrafficked or damaged inner segment material as microvesicles into the interphotoreceptor space. This release may be greatly enhanced under pathological conditions...
Includes: Supplementary data
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Dis Model Mech (2022) 15 (3): dmm049161.
Published: 31 March 2022
... toxicity revealed that dopamine treatment protects against the dose-dependent neurotoxicity caused by cisplatin. C. elegans CRISPR-Cas9 Cisplatin Glucose Mitochondria Neurotoxicity Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 PI15/00895 PI18/00920 PI14...
Includes: Supplementary data
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Journal Articles
Dis Model Mech (2021) 14 (7): dmm048603.
Published: 12 July 2021
... levels ( Chang et al., 2011 ; Bartolome et al., 2013 ), perhaps due to compromised mitochondrial respiration and/or failure to clear damaged mitochondria, which could contribute to VCP disease pathogenesis ( Tanaka et al., 2010 ; Kim et al., 2013 ; Zhang et al., 2017 ; Bento et al., 2018...
Includes: Supplementary data
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Dis Model Mech (2021) 14 (7): dmm048934.
Published: 9 July 2021
... glycolysis Drosophila cancer models Metabolic reprogramming Mitochondria Metabolic reprogramming is a key hallmark of cancer ( Faubert et al., 2020 ). A frequently seen metabolic shift is the Warburg effect that describes the vigorous glucose uptake to fuel glycolysis and secretion of lactate...
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Review Commons
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2020) 13 (10): dmm047134.
Published: 4 November 2020
...) impairing neuronal activity under hyperammonemia. In particular, the early events causing ammonia-induced toxicity to astrocytes are not well understood. Using established cellular HE models, we show that mitochondria rapidly undergo fragmentation in a reversible manner upon hyperammonemia. Further, in our...
Includes: Supplementary data
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Neurodegeneration
Dis Model Mech (2020) 13 (1): dmm040899.
Published: 17 January 2020
.... Summary: Misfolded α-synuclein produced using the protein misfolding cyclic amplification assay associates with cardiolipin and causes hyperactive respiration in neuronal cells. α-Synuclein Synucleinopathy Parkinson's disease Mitochondria Cardiolipin PMCA Parkinson's disease (PD...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (8): dmm033860.
Published: 29 August 2019
... neuroprotection through mitochondria. Considering this, we examined the possible mitochondrial role of pramipexole in promoting neuroprotection following an ischemic stroke of rat. Male Wistar rats underwent transient middle cerebral artery occlusion (tMCAO) and then received pramipexole (0.25 mg and 1 mg/kg body...
Includes: Supplementary data
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Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2018) 11 (9): dmm032698.
Published: 16 August 2018
... work is properly attributed. Summary: A new mouse model has been established that exhibits characteristics of human age-related macular degeneration; the model will facilitate further studies of AMD disease mechanisms. RPE AMD Retinal degeneration PGC-1α High-fat diet Mitochondria...
Includes: Supplementary data
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Dis Model Mech (2018) 11 (3): dmm033027.
Published: 28 March 2018
... potential for chemotaxis. However, it is not known whether mitochondria regulate neutrophil motility in vivo , and the underlying molecular mechanisms remain obscure. Here, we visualized mitochondria in an interconnected network that localizes to the front and rear of migrating neutrophils using a novel...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (3): dmm031625.
Published: 26 March 2018
..., suggesting that mitochondria from ALS patients are characterized by a significant metabolic defect. Taken together, these data indicate that LCLs could be a valid cellular model in ALS research in the identification and study of specific pathological pathways. Mitochondria are highly dynamic organelles...
Includes: Supplementary data
Journal Articles