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Keywords: Mismatch repair
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Journal Articles

Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation

Open Access
In collection:
Cancer Metabolism
Guia Cerretelli, Ying Zhou, Mike F. Müller, David J. Adams, Mark J. Arends
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (8): dmm050240.
https://doi.org/10.1242/dmm.050240
Published: 31 July 2023
...Guia Cerretelli; Ying Zhou; Mike F. Müller; David J. Adams; Mark J. Arends ABSTRACT ALDH1B1 expressed in the intestinal epithelium metabolises acetaldehyde to acetate, protecting against acetaldehyde-induced DNA damage. MSH2 is a key component of the DNA mismatch repair (MMR) pathway involved...
View article titled, Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation
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Includes: Supplementary data