..., the identification of a tumor-specific ‘Achilles' heel’ remains a challenge. Here, we followed an alternative approach, which does not rely on tumor-specific characteristics, but rather uses spatially confined illumination of the light-activatable microtubule inhibitor SBTubA4P to target its cytotoxic activity...

... with cytoplasmic microtubules. Zebrafish ccdc103 / schmalhans ( smh ) mutants have macrophages and neutrophils with reduced proliferation, abnormally rounded cell morphology and an inability to migrate efficiently to the site of sterile wounds, all of which are consistent with a loss of cytoplasmic microtubule...

...Clément Plaud; Vandana Joshi; Natallie Kajevu; Christian Poüs; Patrick A. Curmi; Andrea Burgo ABSTRACT Mutations of the SPG4 ( SPAST ) gene encoding for spastin protein are the main causes of hereditary spastic paraplegia. Spastin binds to microtubules and severs them through the enzymatic activity...

... . We showed that nociceptive sensitivity is associated with disrupted organization of microtubule-associated MAP1B/Futsch and aberrant stabilization of peripheral sensory dendrites. These findings establish a robust and amenable model for studying peripheral mechanisms of CIPN. Using this model, we...