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Keywords: Microcephaly
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Journal Articles
Dis Model Mech (2024) 17 (4): dmm050554.
Published: 1 May 2024
... congenital microcephaly, a condition in which the brain is not properly developed at birth. ANKLE2 is also linked to other disease pathologies, including congenital Zika syndrome, cancer and tauopathy. Here, we review the molecular roles of ANKLE2 and the recent literature on human diseases caused by its...
Journal Articles
Dis Model Mech (2024) 17 (2): dmm050297.
Published: 28 February 2024
..., maternal infection can lead to adverse fetal outcomes. Understanding how ZIKV proteins disrupt development can provide insights into the molecular mechanisms of disease caused by this virus, which includes microcephaly. In this study, we generated a toolkit to ectopically express ZIKV proteins in vivo...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2024) 17 (2): dmm050375.
Published: 28 February 2024
... a declaration by the World Health Organization of an epidemic in the Americas, in which infections were associated with microcephaly. Indeed, prenatal Zika virus infection is detrimental to fetal neural stem cells and can cause premature cell loss and neurodevelopmental abnormalities in newborn infants...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2023) 16 (10): dmm050376.
Published: 11 October 2023
... assays, to notably regulate genes mutated in dyskeratosis congenita ( Rtel1 ), Fanconi anemia ( Fanca ), Diamond–Blackfan anemia ( Tsr2 ), primary microcephaly [ Casc5 (or Knl1 ), Ncaph and Wdr62 ] and pontocerebellar hypoplasia ( Toe1 ). These results provide clues on the role of the p53-DREAM pathway...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (3): dmm049094.
Published: 8 March 2022
... patterning, seizures, microcephaly, and reduced muscle function caused by impaired muscle innervation. This study provides a powerful vertebrate model for investigating CDD disease pathophysiology and allowing high-throughput screening for effective therapies. This article has an associated First Person...
Includes: Supplementary data