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Keywords: Mice
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Journal Articles
Dis Model Mech (2021) 14 (1): dmm046235.
Published: 26 January 2021
...), leading us to question whether patients harboring GJB6 mutations exhibit any brain anomalies. Here, we used mice harboring the human disease-associated A88V Cx30 mutation to address this gap in knowledge. Brain Cx30 levels were lower in male and female Cx30 A88V/A88V mice compared with Cx30 A88V...
Journal Articles
Dis Model Mech (2017) 10 (6): 727–736.
Published: 01 June 2017
..., mucosal intestinal injury consistent with human NEC was induced in postnatal day 14-16 (P14-P16) mice by disrupting Paneth cells, followed by gavage with Klebsiella pneumonia. Mucosal injury was determined by histology, serum cytokine levels and epithelial barrier dysfunction. Toll-like receptor 4 (TLR4...
Journal Articles
Dis Model Mech (2016) 9 (10): 1079–1087.
Published: 01 October 2016
...Bart Ellenbroek; Jiun Youn ABSTRACT Rodents (especially Mus musculus and Rattus norvegicus ) have been the most widely used models in biomedical research for many years. A notable shift has taken place over the last two decades, with mice taking a more and more prominent role in biomedical science...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (7): 779–788.
Published: 01 July 2016
... cavitation does not occur in conventional mouse strains after infection with Mycobacterium tuberculosis , cavitary lung lesions have occasionally been observed in C3HeB/FeJ mice. However, to date, there has been no demonstration that cavitation can be produced consistently enough to support C3HeB/FeJ mice...
Includes: Supplementary data
Journal Articles
In collection:
The RAS Pathway
Dis Model Mech (2015) 8 (8): 769–782.
Published: 01 August 2015
... development. Focusing on studies in mice, zebrafish and Drosophila , we provide an up-to-date review of animal models of RASopathies at the molecular and functional level. We also discuss how increasingly sophisticated techniques of genetic engineering can be used to rigorously connect changes in specific...
Includes: Supplementary data