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Keywords: Metastasis
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Journal Articles
Dis Model Mech (2019) 12 (4): dmm039032.
Published: 01 April 2019
... Mary Stark 100 years ago to today. Cancer Drosophila Mary Stark Metastasis At the beginning of the 20th century, the entomologist Charles W. Woodworth projected the use of Drosophila melanogaster as a genetic model organism ( Sturtevant, 1959 ). Some years later, Thomas Hunt Morgan...
Journal Articles
In collection:
Cancer
Dis Model Mech (2019) 12 (3): dmm036269.
Published: 01 March 2019
... spontaneously metastasising 4T1 mammary gland carcinoma with prolonged development of metastasis ( Pulaski and Ostrand-Rosenberg, 2001 ; Buczek et al., 2018 ; Bailey-Downs et al., 2014 ). This approach permitted quantification of biomarker concentration in plasma in relation to primary tumour growth in early...
Journal Articles
In collection:
Cancer
Dis Model Mech (2018) 11 (10): dmm036236.
Published: 24 October 2018
...Olga S. Blomberg; Lorenzo Spagnuolo; Karin E. de Visser ABSTRACT Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (9): dmm034561.
Published: 27 September 2018
... tumors are highly invasive and eventually metastasize to distant locations, unlike previous transgenic zebrafish melanoma models which do not generally metastasize ( Patton et al., 2005 ). Given the wealth of functionally uncharted genetic lesions discovered from sequencing human tumors, TEAZ allows for...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Dis Model Mech (2018) 11 (9): dmm034199.
Published: 25 September 2018
... laboratories have shown that, following initial tumor cell adhesion to the peritoneal mesothelial monolayer, metastasizing EOC cells induce rapid mesothelial cell retraction to expose the underlying 3D interstitial collagen matrix to which they avidly adhere, and into which they invade to anchor, proliferate...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (5): dmm032250.
Published: 29 May 2018
... in defining the molecular players that drive the various hallmarks of cancer. To determine the molecular regulators of metastasis in TNBC, we completed a rigorous in vitro and in vivo characterisation of four populations of the MDA-MB-231 human breast cancer line ranging in aggressiveness from non...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (8): dmm032920.
Published: 03 May 2018
... Elia , I. , Broekaert , D. , Christen , S. , Boon , R. , Radaelli , E. , Orth , M. F. , Verfaillie , C. , Grunewald , T. G. P. and Fendt , S.-M. ( 2017 ). Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing...
Journal Articles
Dis Model Mech (2018) 11 (3): dmm033100.
Published: 16 March 2018
...Jelle J. F. Sleeboom; Hossein Eslami Amirabadi; Poornima Nair; Cecilia M. Sahlgren; Jaap M. J. den Toonder ABSTRACT Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (1): dmm031146.
Published: 17 January 2018
.... Hipk Metastasis Tumor Cancer A number of evolutionarily conserved signaling pathways are used reiteratively during development to control the growth of healthy organs and tissues. Genetic aberrations in pathway components can lead to dysregulated growth signals, often resulting in...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (9): 1061–1074.
Published: 01 September 2017
...Laura Gómez-Cuadrado; Natasha Tracey; Ruoyu Ma; Binzhi Qian; Valerie G. Brunton ABSTRACT Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body to establish secondary tumors. Although this is an inefficient process, the consequences are devastating as...
Journal Articles
In collection:
Cancer
Dis Model Mech (2017) 10 (1): 3–14.
Published: 01 January 2017
...Jacob L. Albritton; Jordan S. Miller ABSTRACT Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact...
Journal Articles
In collection:
Cancer
Dis Model Mech (2016) 9 (12): 1435–1444.
Published: 01 December 2016
... the organization seen in autochthonous tumors ( Delitto et al., 2015 ). These properties also apply to OS: Rosol and colleagues showed that orthotopic canine OS xenografts in nude mice produced osteoid matrix and metastasized spontaneously, whereas subcutaneous xenografts did not ( Wolfe et al., 2011...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 867–875.
Published: 01 August 2015
... that decreasing miRNA biogenesis promotes metastasis of primary STS in KP mice ( Mito et al., 2013 ). Using unbiased miRNA TaqMan PCR arrays, we profiled resected primary sarcomas from KP mice. We observed that the majority of miRNAs were downregulated in tumors that metastasized to the lungs...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (6): 565–576.
Published: 01 June 2015
... attributed. Summary: We have developed a phenotype-driven screen for identifying new inhibitors of collective cell migration and demonstrated the screen can successfully identify compounds active in vivo and potentially new pathways for targeting cancer metastasis. Drug screening Metastasis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (3): 237–251.
Published: 01 March 2015
... and in vitro . Array-based expression profiling of whole tumours identified genes and pathways that were deregulated in metastatic tumours. EO771.LMB cells metastasised spontaneously to lung in C57BL/6 mice and displayed increased invasive capacity compared with parental EO771. By immunohistochemical...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2014) 7 (3): 387–396.
Published: 01 March 2014
... . Xue   G. , Hemmings   B. A. ( 2013 ). PKB/Akt-dependent regulation of cell motility . J. Natl. Cancer Inst . 105 , 393 – 404 . Yilmaz   M. , Christofori   G. ( 2010 ). Mechanisms of motility in metastasizing cells . Mol. Cancer Res . 8 , 629 – 642 . We also observed...
Includes: Supplementary data