... Drosophila Metastasis Multimorbidity Obesity Therapeutics Tumour diversity Medical Research Council https://search.crossref.org/funding?q=501100000265&from_ui=yes MC-A654-5QC30 Cancer is a systemic disease that can affect several host tissues by metastasising to distant organs...

... Stark 100 years ago to today. Cancer Drosophila Mary Stark Metastasis At the beginning of the 20th century, the entomologist Charles W. Woodworth projected the use of Drosophila melanogaster as a genetic model organism ( Sturtevant, 1959 ). Some years later, Thomas Hunt Morgan...

... metastasising 4T1 mammary gland carcinoma with prolonged development of metastasis ( Pulaski and Ostrand-Rosenberg, 2001 ; Buczek et al., 2018 ; Bailey-Downs et al., 2014 ). This approach permitted quantification of biomarker concentration in plasma in relation to primary tumour growth in early and late...

...Olga S. Blomberg; Lorenzo Spagnuolo; Karin E. de Visser ABSTRACT Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells...

... of multiple germline alleles to obtain the desired combinations. Zebrafish models have advantages in that transgenes can be rapidly tested by mosaic expression, but typically lack spatial and temporal control of tumor onset, which limits their utility for the study of tumor progression and metastasis...

... of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submesothelial matrix to generate metastatic lesions. Metastasis is facilitated by the accumulation of malignant ascites (500 ml to >2 l...

... et al., 2015 ; Fietz et al., 2017 ; Jin et al., 2012 ; Le et al., 2016 ). The relative abilities of the four tumour lines to metastasise spontaneously in vivo were compared side-by-side in a surgical resection model whereby single orthotopic mammary tumours were removed at a similar size...

...Gloria Pascual; Diana Domínguez; Salvador Aznar Benitah; Almut Schulze; Mariia Yuneva ABSTRACT Metastasis remains the leading cause of cancer-related deaths worldwide, and our inability to identify the tumour cells that colonize distant sites hampers the development of effective anti-metastatic...

...Jelle J. F. Sleeboom; Hossein Eslami Amirabadi; Poornima Nair; Cecilia M. Sahlgren; Jaap M. J. den Toonder ABSTRACT Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor...

... metastasis, cells extrude from the main epithelium through various mechanisms, including degradation of the basement membrane by matrix metalloproteinases, such as Mmp1 ( Beaucher et al., 2007 ; Page-McCaw et al., 2003 ; Srivastava et al., 2007 ). Expression of Hipk using either dpp-Gal4 or flip-out...

...Laura Gómez-Cuadrado; Natasha Tracey; Ruoyu Ma; Binzhi Qian; Valerie G. Brunton ABSTRACT Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body to establish secondary tumors. Although this is an inefficient process, the consequences are devastating...

...Jacob L. Albritton; Jordan S. Miller ABSTRACT Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact...

... at the primary site and had greater propensity to disseminate to lung and establish microscopic metastasis. Moreover, OS-2 promoted formation of a different tumor-associated stromal environment than OS-1 xenografts. OS-2-derived tumors comprised a larger percentage of the xenograft tumors than OS-1-derived...

...Mohit Sachdeva; Melody J. Whitley; Jeffrey K. Mito; Yan Ma; Dina C. Lev; Diana M. Cardona; David G. Kirsch ABSTRACT MicroRNAs (miRNAs) can regulate tumor cell invasion and metastasis in a tumor-specific manner. We recently demonstrated that global downregulation of miRNAs after deleting dicer can...

.... Summary: We have developed a phenotype-driven screen for identifying new inhibitors of collective cell migration and demonstrated the screen can successfully identify compounds active in vivo and potentially new pathways for targeting cancer metastasis. Drug screening Metastasis Orthotopic...

... and in vitro . Array-based expression profiling of whole tumours identified genes and pathways that were deregulated in metastatic tumours. EO771.LMB cells metastasised spontaneously to lung in C57BL/6 mice and displayed increased invasive capacity compared with parental EO771. By immunohistochemical...

...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Collective invasion Colorectal cancer model Metastasis Orthotopic injection Single tumour cell Subcutaneous preconditioning Most...