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Keywords: Metabolomics
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Journal Articles
In collection:
Neuromuscular Disease
Dis Model Mech (2022) 15 (10): dmm049492.
Published: 31 October 2022
... aggregation. Metabolomics analysis of HD patients and of a yeast model of HD was, therefore, carried out. Our analysis showed a considerable overlap of deregulated metabolic pathways. Further, the multi-omics analysis showed deregulated pathways common in human, mice and yeast model systems, and those...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2022) 15 (8): dmm049550.
Published: 16 August 2022
... metabolome analysis in the adult zebrafish. As a proof of concept, we quantitatively determined the whole-body distribution of the anti-rheumatic agent hydroxychloroquine sulfate (HCQ) and measured the systemic metabolic impacts of drug treatment. We found that HCQ distributed to most organs in the adult...
Includes: Supplementary data
Journal Articles
Journal Articles
Series: REVIEW COMMONS TRANSFER
Dis Model Mech (2021) 14 (4): dmm047746.
Published: 27 April 2021
... Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand; for instance, in research related to nutrition and aging. The nematode Caenorhabditis elegans is a key model organism in these fields, owing to the large repository of available C. elegans mutants and their convenient...
Includes: Supplementary data
Journal Articles
Journal Articles
Dis Model Mech (2019) 12 (2): dmm035980.
Published: 8 February 2019
... (sFlt-1) and lipopolysaccharide (LPS) administration at mid-gestation in pregnant mice resulted in hypertension and albuminuria comparable to that of the manifestation in humans. A metabolomics analysis revealed that pre-eclamptic dams have increased plasma concentrations of phosphadytilcholines...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (10): 1229–1243.
Published: 1 October 2017
... in the plasma, liver and adipose tissue. The obese-specific metabolic response to stroke was assessed in plasma using non-targeted ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) metabolomics coupled with univariate and multivariate analysis. Obesity had no effect on the extent...