... embryogenesis. Loss-of-function mutations in PTCH1 are associated with altered neuronal development and the malignant brain tumour medulloblastoma. As a result of differences between murine and human development, molecular and cellular perturbations that arise from human PTCH1 mutations remain poorly understood...

... and proliferative properties during development. Recent data suggest that co-opted temporal patterning could govern tumor growth in neural cancers with developmental origins. Drosophila Pediatric cancer Neural stem cell Temporal patterning Medulloblastoma Centre National de la Recherche...

...Ravinder Kaur; Christopher Aiken; Ludivine Coudière Morrison; Radhika Rao; Marc R. Del Bigio; Shravanti Rampalli; Tamra Werbowetski-Ogilvie ABSTRACT Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor and is currently divided into four subtypes based on different genomic...

... carcinoma. Moreover, live imaging analysis of the exocrine pancreatic tissue revealed an increasing number of KRAS-positive cells and progressive activation of TGFβ and Notch pathways. Increase in TGFβ, following KRAS G12D activation, was confirmed in a concomitant model of medulloblastoma (MDB). Notch...