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Keywords: Macrophages
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Journal Articles
Dis Model Mech dmm.044669.
Published: 29 April 2021
... regeneration. Additionally, we demonstrate that glia and macrophages contribute to functional regeneration through mechanisms involving the c-Jun N-terminal kinase (JNK) pathway and Draper, characteristic of other neural injury paradigms. We show that macrophages are recruited to the injury site and are...
Journal Articles
Dis Model Mech (2020) 13 (7): dmm043091.
Published: 20 July 2020
... are cleared in vivo , we further analyzed Toxoplasma- macrophage interactions using time-lapse microscopy and three-dimensional correlative light and electron microscopy (3D CLEM). Time-lapse microscopy revealed that macrophages are recruited to the infection site and play a key role in Toxoplasma...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (1): dmm041962.
Published: 24 January 2020
...Sarah Colijn; Vijay Muthukumar; Jun Xie; Siqi Gao; Courtney T. Griffin ABSTRACT Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage necroptosis. However, RIPK3 has been connected to numerous other...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (1): dmm041889.
Published: 09 January 2020
...Emily E. Rosowski ABSTRACT The specific roles of the two major innate immune cell types – neutrophils and macrophages – in response to infection and sterile inflammation are areas of great interest. The larval zebrafish model of innate immunity, and the imaging capabilities it provides, is a source...
Journal Articles
Dis Model Mech (2019) 12 (5): dmm038711.
Published: 15 May 2019
... of ADORA2B and HAS3 were detected in CPFE and in our experimental model of CPFE. Treatment with 4MU was able to attenuate PH and fibrosis but not airspace enlargement. This was accompanied by a reduction of HAS3-positive macrophages. We have generated pre-clinical data demonstrating the capacity of...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (4): dmm037390.
Published: 05 April 2019
... renal injury, we showed that delivery of PTBA using an esterified prodrug (UPHD25) increases the reactivation of the renal progenitor gene Pax2a , enhances dedifferentiation of RTECs, reduces Kidney injury molecule-1 (Kim-1) expression, and lowers the number of infiltrating macrophages. Further, we...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (3): dmm037762.
Published: 08 March 2019
...Laura E. Kuil; Nynke Oosterhof; Samuël N. Geurts; Herma C. van der Linde; Erik Meijering; Tjakko J. van Ham ABSTRACT Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2016) 9 (9): 1051–1061.
Published: 01 September 2016
... results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in this process, promoting cyst epithelial cell proliferation, cyst expansion and disease progression. Previously, we have shown that the microenvironment...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (11): 1375–1388.
Published: 01 November 2015
... infection was increased upon immunosuppressant treatment. We showed for the first time that macrophages and neutrophils were readily recruited in vivo to the site of infection in an intact host and that spore phagocytosis can be observed in real-time in vivo . While exploring innate immune effector...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2015) 8 (8): 817–829.
Published: 01 August 2015
... of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we performed transcriptomic analysis in macrophages and identified a subgroup of individuals with CD who had low...
Includes: Supplementary data