... development, the myeloid lineage was affected, resulting in a decrease in the number of neutrophils and a concomitant increase in the number of macrophages. The number of emerging hematopoietic stem and progenitor cells (HSPCs) was decreased, but due to hyperproliferation, the number of HSPCs was higher...

... the mechanisms of tumour angiogenesis and as an assay to screen anti-angiogenic compounds. In this study, we used cell ablation techniques to remove either macrophages or neutrophils and assessed their contribution towards zebrafish xenograft angiogenesis by quantitating levels of graft vascularisation...

... cartilage regeneration in vivo . Cartilage p21 Mesenchymal stem cells Regeneration Macrophage Approximately one in eight individuals suffer from osteoarthritis (OA), a disease characterized by degeneration of the cartilage surfaces of the joints with resulting pain and disability. Within...

... Q61K , HRas G12V and KRas G12V ) in melanocytes, leading to proliferation and changes in morphology of the melanocytes. This model was coupled to binary cell-specific biotagging models allowing in vivo biotinylation and subsequent isolation of macrophage or neutrophil nuclei for regulatory profiling...

... with the host immune cells (macrophages and neutrophils) to clear Shigella infection in vivo , before being cleared by the zebrafish immune system themselves. Next, an in-depth investigation of Bdellovibrio predation on a range of Gram-negative pathogens using the zebrafish model is needed before...

... by Schistosoma japonicum eggs, as manifested by reduced body weight loss and attenuated hepatomegaly along with preserved liver function. Notably, S. japonicum infection induced high levels of hepatic Cx3cr1 expression, which was predominantly expressed by infiltrating macrophages. Loss of Cx3cr1 rendered...