... survivorship pain, cisplatin induced a neuroinflammatory environment in the dorsal root ganglia (DRG), demonstrated by NGF-positive macrophages infiltrating into the DRG. Cisplatin-treated CD11b- and F4/80-positive macrophages expressed more NGF compared to those treated with vehicle control. Mouse primary DRG...

... to fungal pathogens. Paradoxically, metals may also support fungal virulence. Copper Fungal immunology Iron Macrophage Nutritional immunity Medical Research Council http://dx.doi.org/10.13039/501100007155 MR/S024611 Saudi Arabian Cultural Bureau http://dx.doi.org/10.13039...

... is expressed in subsets of neutrophils and macrophages, potentially representing anti-inflammatory, polarised immune cell populations. Our findings identify nuanced responses to immune challenge in vivo, responses that represent new opportunities for therapeutic interventions during inflammation and infection...

... development, the myeloid lineage was affected, resulting in a decrease in the number of neutrophils and a concomitant increase in the number of macrophages. The number of emerging hematopoietic stem and progenitor cells (HSPCs) was decreased, but due to hyperproliferation, the number of HSPCs was higher...

... the mechanisms of tumour angiogenesis and as an assay to screen anti-angiogenic compounds. In this study, we used cell ablation techniques to remove either macrophages or neutrophils and assessed their contribution towards zebrafish xenograft angiogenesis by quantitating levels of graft vascularisation...

... cartilage regeneration in vivo . Cartilage p21 Mesenchymal stem cells Regeneration Macrophage Stem Cell Network 10.13039/501100000098 Canadian Institutes of Health Research 10.13039/501100000024 201309MOP-311542-CIB University of Calgary 10.13039/100008459...

... Q61K , HRas G12V and KRas G12V ) in melanocytes, leading to proliferation and changes in morphology of the melanocytes. This model was coupled to binary cell-specific biotagging models allowing in vivo biotinylation and subsequent isolation of macrophage or neutrophil nuclei for regulatory profiling...

... in both infection and cell biology. Antimicrobial resistance Autophagy Cytoskeleton Emergency granulopoiesis Inflammation Macrophage Neutrophil Septin Shigella Zebrafish Wellcome Trust 10.13039/100010269 206444/Z/17/Z WT097411MA Lister Institute of Preventive...

... by Schistosoma japonicum eggs, as manifested by reduced body weight loss and attenuated hepatomegaly along with preserved liver function. Notably, S. japonicum infection induced high levels of hepatic Cx3cr1 expression, which was predominantly expressed by infiltrating macrophages. Loss of Cx3cr1 rendered...