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Keywords: MRTF-A–SRF signaling
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Journal Articles

Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation

Open Access
In collection:
Cancer , Drosophila as a Disease Model
Lídia Faria, Sara Canato, Tito T. Jesus, Margarida Gonçalves, Patrícia S. Guerreiro, Carla S. Lopes, Isabel Meireles, Eurico Morais-de-Sá, Joana Paredes, Florence Janody
Journal: Disease Models & Mechanisms
Dis Model Mech (2023) 16 (2): dmm049652.
https://doi.org/10.1242/dmm.049652
Published: 21 February 2023
... translocation hampers proliferation, self-renewal and invasion. Thus, in addition to sustaining malignant phenotypes, P-cadherin can also play a major role in the early stages of breast carcinogenesis by promoting a transient boost of MRTF-A–SRF signaling through actin regulation. We have previously reported...
View articletitled, Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation
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Includes: Supplementary data