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Keywords: Lysyl oxidase
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Journal Articles
In collection:
Genetic Variance in Human Disease
Maria F. Suarez, Heather M. Schmitt, Megan S. Kuhn, TeddiJo Watkins, Kristyn M. Hake, Tara Weisz, Edward J. Flynn, III, Michael H. Elliott, Michael A. Hauser, W. Daniel Stamer
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (11): dmm050392.
Published: 13 November 2023
... matrix deposits. Its most significant ocular manifestation is an aggressive form of glaucoma associated with variants in the gene encoding lysyl oxidase-like 1 ( LOXL1 ). Depending upon the population, variants in LOXL1 can impart risk or protection for PEX, suggesting the importance of genetic context...
Includes: Supplementary data
Journal Articles
Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (11): 1301–1312.
Published: 1 November 2017
... of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease pathogenesis and represent a therapeutic target. This study aimed to further our understanding of the mechanisms by which LO inhibitors might improve lung fibrosis...
Includes: Supplementary data
Journal Articles
María Miana, María Galán, Ernesto Martínez-Martínez, Saray Varona, Raquel Jurado-López, Belén Bausa-Miranda, Alfonso Antequera, María Luaces, José Martínez-González, Cristina Rodríguez, Victoria Cachofeiro
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (6): 543–551.
Published: 1 June 2015
... in the pathophysiology of obesity. The lysyl oxidase (LOX) family of amine oxidases, including LOX and LOX-like (LOXL) isoenzymes, controls ECM maturation, and upregulation of LOX activity is essential in fibrosis; however, its involvement in adipose tissue dysfunction in obesity is unclear. In this study, we observed...