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Keywords: Lysyl oxidase
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Journal Articles
Dis Model Mech (2023) 16 (11): dmm050392.
Published: 13 November 2023
... matrix deposits. Its most significant ocular manifestation is an aggressive form of glaucoma associated with variants in the gene encoding lysyl oxidase-like 1 ( LOXL1 ). Depending upon the population, variants in LOXL1 can impart risk or protection for PEX, suggesting the importance of genetic context...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2017) 10 (11): 1301–1312.
Published: 1 November 2017
... of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease pathogenesis and represent a therapeutic target. This study aimed to further our understanding of the mechanisms by which LO inhibitors might improve lung fibrosis...
Includes: Supplementary data
Journal Articles