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Keywords: Lymphomas
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Journal Articles
Donald M. Salter, Meredyth Griffin, Morwenna Muir, Katy Teo, Jayne Culley, James R. Smith, Laura Gomez-Cuadrado, Kylie Matchett, Andrew H. Sims, Larry Hayward, Neil C. Henderson, Valerie G. Brunton
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (7): dmm038612.
Published: 9 July 2019
... cells, mice developed angiosarcomas with 100% penetrance upon homozygous deletion of Trp53 with a median lifespan of 325 days. In contrast, expression of the R172H mutant p53 resulted in formation of thymic lymphomas with a more rapid onset (median lifespan 151 days). We also used Pdgfrb-Cre -expressing...
Includes: Supplementary data