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Keywords: Lung adenocarcinoma
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Journal Articles
Dis Model Mech dmm.049072.
Published: 08 September 2021
... of murine EGFR -mutant lung adenocarcinomas in the absence of a transgenic allele containing human DTR. DT enzymatic activity was required for tumor regression, and EGFR-mutant tumor cells were the primary targets of DT toxicity. In FVB mice, EGFR -mutant tumors upregulated expression of HB-EGF, which...
Journal Articles
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Dis Model Mech (2019) 12 (2): dmm036863.
Published: 12 February 2019
... clinical diagnosis of lung adenocarcinoma, the potential for cfDNA and ctDNA as early detection biomarkers remains unexplored. Here, using a Cre-regulated genetically engineered mouse model of lung adenocarcinoma development, driven by Kras G12D (the Kras LSL-G12D mouse), we serially tracked the release...
Includes: Supplementary data