... identified as a critical regulator of embryonic liver development, NOTCH signalling activation has been associated with the pathogenesis of a number of paediatric and adult liver diseases. It remains unclear, however, what role NOTCH actually plays in these pathophysiological processes and whether NOTCH...

...Anabel Martinez Lyons; Luke Boulter ABSTRACT The Notch signaling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence...

... in the enzyme glucose-6-phosphatase-α (G6Pase-α), develop renal and liver complications, including the development of hepatocellular adenoma/carcinoma. The purpose of this study was to identify potential biomarkers of the pathophysiology of the GSD1a-affected liver. To this end, we used the plasma exosomes...

...Sofia de Oliveira; Ruth A. Houseright; Benjamin G. Korte; Anna Huttenlocher ABSTRACT Fibrolamellar carcinoma (FLC) is a rare liver cancer that affects adolescents and young adults. Genomic analysis of FLC has revealed a 400 kb deletion in chromosome 19 that leads to the chimeric transcript DNAJB1...

... clearly distinguishable from those exhibited by low-risk adenomas, suggesting the possibility of applying MRI to humans for non-invasive diagnostic purposes. Liver Tumor Magnetic resonance β-Catenin Associazione Italiana per la Ricerca sul Cancro 10.13039/501100005010 IG15461...

... receptor isoforms Adeno-associated virus (AAVs) Liver Ministerio de Ciencia e Innovación 10.13039/501100004837 SAF2011/22555 SAF2014-51795-R Comunidad de Madrid S2010/BMD-2423 CIBER de Diabetes y Enfermedades Metabólicas Asociadas PIE14/00061 Type 2...

... genes in the central nervous system, heart, liver and kidney, and provide examples of the use of these assays to address questions related to human diseases. These assays provide us with simple yet powerful tools to study the pathogenic mechanisms associated with human disease-causing genes. ERG...

.../by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Labrador retrievers with hereditary copper toxicosis are a useful new model for copper-metabolism disorders. ATP7A ATP7B Dog Liver...

... with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are elevated in chronic liver diseases, including fatty liver diseases associated with obesity and alcoholic ingestion. In this study, we further...