..., as these mechanisms could provide attractive therapeutic targets for cancer. Cellular lipid metabolism is tightly regulated and responsive to environmental stimuli. Thus, lipid metabolism in cancer is heavily influenced by the tumor microenvironment. In this Review, we outline the mechanisms by which the tumor...

..., the homolog of human ATGL ( Patel et al., 2022 ), in the mechanism that drives macrophage infiltration in the fat tissue (ATM). Previous research in flies has demonstrated that mutations in the brummer gene or alterations in its expression affect lipid metabolism and fat storage ( Gronke et al., 2005...

... in body weight ( Grönke et al., 2010 ; Murillo-Maldonado et al., 2011 ). We demonstrate that fat body expression of trbl causes a decrease in the body weight of flies, further supporting the role of trbl as a negative regulator of insulin signalling. Insulin signalling controls lipid metabolism...

... induction of TOR independently of the Immune deficiency (IMD) innate immune pathway, and we see that TOR functions together with IMD signalling to promote infection survival. These protective effects of TOR signalling are associated with remodelling of host lipid metabolism. Thus, we see that TOR...

... levels of thermogenic uncoupling protein 1 in BAT in PGC-1β-AT-KO and wild-type mice. Gene expression in BAT of mutant mice suggested a compensatory increase in lipid metabolism to counteract the thermogenic defect. Interestingly, a reduced number of contacts between mitochondria and lipid droplets...

... previously verified, hepatic lipid metabolism dysregulation prevails in NAFLD ( Arab et al., 2018 ; Friedman et al., 2018 ). Expression of key proteins involved in lipid metabolism and NAFLD progression, such as acetyl-CoA carboxylase (ACC; encoded by Acaca ), fatty acid synthase (FAS; encoded by Fasn...

... with epithelial–mesenchymal transition, in addition to glomerular basement membrane thickening and podocyte foot process effacement associated with albuminuria. Also evident was insulin resistance and oxidative stress at the renal level, together with aberrant renal lipid metabolism and mitochondrial function...