... connection of microglia to leukodystrophies, genetic disorders of the white matter, has highlighted their involvement in the maintenance of white matter integrity. However, the mechanisms that underlie their putative roles in these processes remain largely uncharacterized. Microglia have also been gaining...

...Marina R. Carpinelli; Anne K. Voss; Michael G. Manning; Ashwyn A. Perera; Anne A. Cooray; Benjamin T. Kile; Rachel A. Burt Canavan disease is a leukodystrophy caused by mutations in the ASPA gene. This gene encodes the enzyme that converts N-acetylaspartate into acetate and aspartic acid...