... of Jak2/Stat5. Restoration of Socs2 blocks Nras G12D HSC reconstitution in bone marrow transplant recipients. SOCS2 downregulation is also observed in human acute myeloid leukemia (AML) cells that carry RAS mutations. RAS mutant AML cells exhibited suppression of the enhancer active marker H3K27ac...

... myeloid leukemia model induced by human KRAS G12V , which exhibits a dramatic increase in myeloid-like leukemia cells. We performed both genetic and drug screens using this model. The genetic screen identified 24 candidate genes able to attenuate the oncogenic RAS -induced phenotype, including two key...

... MPNSTs, including leukemia with histological characteristics of lymphoid malignancies, soft tissue sarcoma and pancreatic adenocarcinoma, which were not detected in p53/nf1- deficient control fish, and are also contained in the human spectrum of SUZ12 -deficient malignancies identified in the AACR Genie...

... summarize the last 20 years of research in zebrafish models for hematopoietic disorders, highlighting how these models were created and are being applied for translational research. Disease models Hematopoiesis Blood disorders Leukemia Immunodeficiency Bone marrow failure syndrome Swiss...

...Brian Chipman Belyea; Fang Xu; Maria Luisa Soledad Sequeira-Lopez; Roberto Ariel Gomez ABSTRACT Conditional deletion of RBP-J , the major transcriptional effector of Notch signaling, specifically within renin-expressing cells leads to the development of B-cell leukemia. However, the influence...