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Keywords: Kinesin light chain
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Journal Articles
Selin Gümüşderelioğlu, Lauren Resch, Trisha Brock, Undiagnosed Diseases Network, G. W. Gant Luxton, Heidi Cope, Queenie K.-G. Tan, Christopher Hopkins, Daniel A. Starr
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (8): dmm050076.
Published: 29 August 2023
... kinesin light chain 4 ( KLC4 ) that is suspected to be associated with autosomal-dominant HSP. How this and other variants relate to pathologies is unknown. We created a humanized Caenorhabditis elegans model in which klc- 2 was replaced by human KLC4 (referred to as hKLC4 ) and assessed the extent...
Includes: Supplementary data