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1-9 of 9
Keywords: Kidney
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Journal Articles
Mackenzie Thornton, Nicole Sommer, Mercedes McGonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, Praveen V. Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela V. Tran, Timothy A. Fields, Patricio E. Ray, Navneet K. Dhillon, Madhulika Sharma
Journal:
Disease Models & Mechanisms
Dis Model Mech dmm.052056.
Published: 6 February 2025
... proteins and inflammation. We found activation of Notch3 in renal cells of the HIV-1 mouse model (HIV-Tg26) and in patients with HIV associated nephropathy. We hypothesized that targeting Notch3 activation constitutes an effective therapy for HIV-related chronic kidney diseases (HIV-CKD). We generated HIV...
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2024) 17 (2): dmm050447.
Published: 14 February 2024
...Scarlet Xiaoyan Wang; Andrea Streit ABSTRACT The association between ear and kidney anomalies has long been recognized. However, little is known about the underlying mechanisms. In the last two decades, embryonic development of the inner ear and kidney has been studied extensively. Here, we...
Journal Articles
Julie Bejoy, Justin M. Farry, Eddie S. Qian, Curtis H. Dearing, Lorraine B. Ware, Julie A. Bastarache, Lauren E. Woodard
Journal:
Disease Models & Mechanisms
Dis Model Mech (2023) 16 (12): dmm050342.
Published: 1 December 2023
...Julie Bejoy; Justin M. Farry; Eddie S. Qian; Curtis H. Dearing; Lorraine B. Ware; Julie A. Bastarache; Lauren E. Woodard ABSTRACT Sepsis-associated acute kidney injury is associated with high morbidity and mortality in critically ill patients. Cell-free hemoglobin (CFH) is released...
Includes: Supplementary data
Journal Articles
In collection:
Human Genetic Disease
Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak
Journal:
Disease Models & Mechanisms
Dis Model Mech (2021) 14 (8): dmm048952.
Published: 5 August 2021
... sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal segmental...
Includes: Supplementary data
Journal Articles
Journal:
Disease Models & Mechanisms
Dis Model Mech (2019) 12 (4): dmm038604.
Published: 9 April 2019
...Alexandria T. M. Blackburn; Rachel K. Miller ABSTRACT Congenital anomalies of the kidney and urinary tract (CAKUT) occur in ∼1/500 live births and are a leading cause of pediatric kidney failure. With an average wait time of 3-5 years for a kidney transplant, the need is high for the development...
Journal Articles
Sian E. Piret, Eric Olinger, Anita A. C. Reed, M. Andrew Nesbit, Tertius A. Hough, Liz Bentley, Olivier Devuyst, Roger D. Cox, Rajesh V. Thakker
Journal:
Disease Models & Mechanisms
Dis Model Mech (2017) 10 (6): 773–786.
Published: 1 June 2017
... and inherited renal disorders. However, the mechanisms of renal fibrosis are incompletely understood and we therefore explored these by establishing a mouse model for a renal tubular disorder, referred to as autosomal dominant tubulointerstitial kidney disease (ADTKD) due to missense uromodulin ( UMOD...
Includes: Supplementary data
Journal Articles
In collection:
Neurodegenerative Disorders
Journal:
Disease Models & Mechanisms
Dis Model Mech (2016) 9 (3): 235–244.
Published: 1 March 2016
... genes in the central nervous system, heart, liver and kidney, and provide examples of the use of these assays to address questions related to human diseases. These assays provide us with simple yet powerful tools to study the pathogenic mechanisms associated with human disease-causing genes. ERG...
Includes: Supplementary data
Journal Articles
Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (10): 1227–1236.
Published: 1 October 2015
... mimic the complex in vivo milieu. Therefore, we here evaluated a precision-cut kidney slice (PCKS) model as a new, multicellular ex vivo model to study the development of fibrosis and its prevention using anti-fibrotic compounds. Precision-cut slices (200-300 μm thickness) were prepared from healthy...
Journal Articles
Xin Wan, Li-Jun Hou, Li-Yuan Zhang, Wen-Juan Huang, Lin Liu, Qian Zhang, Bo Hu, Wen Chen, Xin Chen, Chang-Chun Cao
Journal:
Disease Models & Mechanisms
Dis Model Mech (2015) 8 (7): 733–742.
Published: 1 July 2015
...Xin Wan; Li-Jun Hou; Li-Yuan Zhang; Wen-Juan Huang; Lin Liu; Qian Zhang; Bo Hu; Wen Chen; Xin Chen; Chang-Chun Cao ABSTRACT The recovery phase after kidney ischemia/reperfusion (IR) injury is often associated with the suppression of inflammation and the proliferation of tubular epithelial cells...
Includes: Supplementary data