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Keywords: Insulin secretion
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Journal Articles
Dis Model Mech (2018) 11 (6): dmm033316.
Published: 13 June 2018
.... β-cell-targeted GCK transduction did not change glucose handling in chow-fed C57BL/6 mice. Although adult mice fed a HFD showed reduced islet GCK expression, impaired glucose tolerance and decreased glucose-stimulated insulin secretion (GSIS), β-cell-targeted GCK transduction improved glucose...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2016) 9 (1): 51–61.
Published: 1 January 2016
... of Langerhans and plays a role in the modulation of insulin secretion and expansion of the β-cell mass. The downstream signalling pathways mediating these effects are poorly understood. Mammalian target of rapamycin complex 1 (mTORC1) signalling is a key intracellular pathway involved in energy homeostasis...
Includes: Supplementary data