... by insulin resistance. We found that attenuation of Eiger/TNFα signaling reduced ATM and improved insulin sensitivity. Furthermore, using metformin and the antioxidants anthocyanins, we ameliorated both phenotypes. Our data highlight evolutionarily conserved mechanisms allowing the development of Drosophila...

.... As a NAFLD model, we used apolipoprotein E-deficient mice administered a high-fat diet for 8 or 18 weeks. We demonstrated that insulin resistance and decreased lipogenesis and autophagy observed after 18 weeks on the diet are related to a concerted regulation carried out by miR-26b-5p, miR-34a-5p, miR-149-5p...

... reported PN sex dimorphism in obese leptin-deficient ob / ob mice. This genetic model is inherently limited, however, owing to leptin's role in metabolism. Therefore, the current study goal was to examine PN and insulin resistance in male and female C57BL6/J mice fed a high-fat diet (HFD), an established...

... sheep raised on a high-calorie carbohydrate-rich diet develop hyperglycemia, hyperinsulinemia, insulin resistance, and hepatic steatosis. Here, we tested the hypothesis that treatment with thiamine (vitamin B1) can counter the development of hepatic steatosis driven by overnutrition. Remarkably...

...Andrea Raposo Lopez-Pastor; Almudena Gomez-Hernandez; Sabela Diaz-Castroverde; Gloria Gonzalez-Aseguinolaza; Agueda Gonzalez-Rodriguez; Gema Garcia; Silvia Fernandez; Oscar Escribano; Manuel Benito ABSTRACT Among the main complications associated with obesity are insulin resistance and altered...

... characterized by insulin resistance and cardiac lipotoxicity. Galectin-3 (Gal-3) induces cardiac inflammation and fibrosis in the context of obesity; however, its role in the metabolic consequences of obesity is not totally established. We have investigated the potential role of Gal-3 in the cardiac metabolic...

...Jian-Hua Chen; Kim Jee Goh; Nuno Rocha; Matthijs P. Groeneveld; Marina Minic; Timothy G. Barrett; David Savage; Robert K. Semple ABSTRACT Adipose tissue is the primary tissue affected in most single gene forms of severe insulin resistance, and growing evidence has implicated it as a site at which...

...Philip M. Coan; Oliver Hummel; Ana Garcia Diaz; Marjorie Barrier; Neza Alfazema; Penny J. Norsworthy; Michal Pravenec; Enrico Petretto; Norbert Hübner; Timothy J. Aitman ABSTRACT We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12...

... insufficiency in the context of ongoing insulin resistance. Although genetic susceptibility is thought to govern the propensity of individuals to develop type 2 diabetes mellitus under appropriate environmental conditions, many of the human genes associated with the disease in genome-wide association studies...

... weight is in keeping with previous reports in STZ-administered rats ( Huang et al., 2013 ). The more rapid onset of visual decline and the slower treatment response in the DD group are also consistent with insulin resistance as a cause of diabetic visual dysfunction. Because the addition of STZ has been...

... the downregulation of adiponectin and glucose transporter 4 (GLUT4), as well as the increase in suppressor of cytokine signaling 3 (SOCS3) and dipeptidyl peptidase 4 (DPP4) levels, triggered by the HFD. Likewise, in the TNFα-induced insulin-resistant 3T3-L1 adipocyte model, BAPN prevented the downregulation...