... largely unknown. Here, we elucidate the earliest cellular mechanisms involved in BCG-induced tumor clearance. We developed a fast preclinical in vivo assay to visualize in real time and at single-cell resolution the initial interactions among bladder cancer cells, BCG and innate immunity using...

... with mitochondrial dysfunction and activation of a type I interferon response by cytosolic mitochondrial DNA. Friedreich ataxia Cardiomyopathy mtDNA Interferon Innate immunity Hamilton and Finneran Families Friedreich's Ataxia Research Alliance http://dx.doi.org/10.13039/100002108...

... influences life-long fitness is not well understood. Using Drosophila as a model, we find that activation of innate immune pathway Immune deficiency (Imd) signalling in the developing larvae increases adult starvation resistance, decreases food intake and shortens organismal lifespan. Interestingly, lifespan...

...Emily E. Rosowski ABSTRACT The specific roles of the two major innate immune cell types – neutrophils and macrophages – in response to infection and sterile inflammation are areas of great interest. The larval zebrafish model of innate immunity, and the imaging capabilities it provides, is a source...

...Mayo Araki; Massanori Kurihara; Suzuko Kinoshita; Rie Awane; Tetsuya Sato; Yasuyuki Ohkawa; Yoshihiro H. Inoue ABSTRACT The innate immune response is the first line of defence against microbial infections. In Drosophila , two major pathways of the innate immune system (the Toll- and Imd-mediated...

...Hiroyuki Kenmoku; Aki Hori; Takayuki Kuraishi; Shoichiro Kurata ABSTRACT Drosophila adults have been utilized as a genetically tractable model organism to decipher the molecular mechanisms of humoral innate immune responses. In an effort to promote the utility of Drosophila larvae as an additional...

... and the associated host innate immune response. * Present address: National Institutes of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. ‡ Present address: University of Pennsylvania, 3451 Walnut Street, Philadelphia, PA 19104, USA. § Author...

... the relevance of cellular and molecular processes that are fundamental to the cell-mediated innate immune response. In particular, various recently established zebrafish infectious disease models are contributing substantially to our understanding of the mechanisms by which different pathogens interact...