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Keywords: Inflammation
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Journal Articles
Dis Model Mech (2021) 14 (3): dmm048041.
Published: 24 March 2021
... hyperuricemia-related diseases. Hyperuricemia-induced autophagy and NLRP3-dependent inflammation are critically involved in the development of renal damage and, therefore, highlight the inhibition of autophagy and inflammation in search of therapeutic strategies to treat uric acid nephropathy. A number of...
Journal Articles
Dis Model Mech (2021) 14 (3): dmm047001.
Published: 19 March 2021
... transformed cells, supported parallels between chordomas, wound and inflammation. Cancerous notochordal cells interfere with differentiation of sheath cells to form chordacentra domains, leading to fusions and vertebral clefts during development. Adults displayed IVD irregularities reminiscent of degeneration...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (12): dmm046383.
Published: 29 December 2020
... of AH in mice and compared the nature of liver injury in C57/BL6 wild-type (WT) versus Nrf2 −/− mice. Our data showed that both WT and Nrf2 −/− mice demonstrate robust weight loss, and an increase in serum transaminase, steatosis and hepatic inflammation when exposed to diet and ethanol. This is...
Includes: Supplementary data
Journal Articles
In collection:
Metabolic Disorders
Dis Model Mech (2020) 13 (12): dmm045351.
Published: 18 December 2020
... proliferation, and leukocyte infiltration in pancreata in mouse models of diabetes. Light-sheet fluorescence microscopy Tissue clearing Beta cells Insulin Inflammation Diabetes is a life-threatening chronic disease that arises when the body is unable to regulate blood glucose homeostasis...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (11): dmm043620.
Published: 01 December 2020
...Jiang-Hua Liu; Tao Yue; Zhong-Wei Luo; Jia Cao; Zi-Qi Yan; Ling Jin; Teng-Fei Wan; Ci-Jun Shuai; Zheng-Guang Wang; Yong Zhou; Ran Xu; Hui Xie ABSTRACT Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (9): dmm046441.
Published: 21 September 2020
... debilitating condition and discuss approaches to solving this clinical puzzle. Bone morphogenetic protein ACVR1 Fibrodysplasia ossificans progressiva Heterotopic ossification Inflammation Skeletal bone formation, also known as osteogenesis or ossification (see Glossary of clinical terms, Box...
Journal Articles
Dis Model Mech (2020) 13 (6): dmm042556.
Published: 26 June 2020
... that animals treated with 0.5, 1 and 2.5 µg/ml doxycycline showed hyperglycemia without an associated increase in Casp3* expression in these embryos. References Ambade , A. and Mandrekar , P. ( 2012 ). Oxidative stress and inflammation: essential partners in alcoholic liver disease...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (5): dmm042648.
Published: 01 June 2020
... inflammation. Here, we show that genetic activation of the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nfe2l2/Nrf2) in keratinocytes of Spink5 knockout mice, a model for Netherton syndrome, significantly alleviates their cutaneous phenotype. Nrf2 activation promoted attachment of the...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (4): dmm042564.
Published: 30 April 2020
... live imaging of early innate immune inflammation. Expression of zfDnaJa-Pkaca in hepatocytes induces hepatomegaly and increased hepatocyte size. In addition, FLC larvae exhibit early innate immune inflammation characterized by early infiltration of neutrophils and macrophages into the liver...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (3): dmm042515.
Published: 30 March 2020
...; however, transcriptomic and immunohistochemical profiling of several markers of inflammation revealed no innate immune activation in Arx (GCG)10+7 cortex. Neither neonatal E2 hormone therapy, nor ACTH(1-24), the frontline clinical therapy for ISSX, diminished the augmented apoptosis in Arx (GCG)10+7 , but...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2020) 13 (2): dmm043638.
Published: 02 March 2020
... strongly focus on myonecrosis and the associated inflammation and oxidative stress in DMD muscle, as the lack of dystrophin causes repeated bouts of myonecrosis, which are the key events that initiate the resultant severe dystropathology. We discuss the early events of intrinsic myonecrosis, along with...
Journal Articles
Dis Model Mech (2019) 12 (12): dmm040642.
Published: 17 December 2019
... improvement in renal function and a significant decrease in mortality compared to Tg26 mice. Histological examination of kidneys showed that Notch4 d1 /Tg26 + mice had overall glomerular, tubulointerstitial injury and a marked decrease in interstitial inflammation. A significant decrease in the proliferating...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (12): dmm041384.
Published: 16 December 2019
... of IL-1β, IL-6, Mmp3, Mmp9, CX3CL1 and epiregulin, which has been reported to contribute to inflammation, wound healing and tissue repair. Furthermore, we demonstrate that inhibition of the Fkn receptor blocked tendon cell migration in vitro , and show the presence of CX3CL1/CX3CR1/EREG-expressing...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (5): dmm037887.
Published: 30 May 2019
... order to improve glucocorticoid therapies, more research is required into the mechanisms of glucocorticoid action. In the present study, we have used a zebrafish model for inflammation to study glucocorticoid effects on the innate immune response. In zebrafish larvae, the migration of neutrophils...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2019) 12 (1): dmm036004.
Published: 23 January 2019
...Luis Fernando Delgadillo-Silva; Anastasia Tsakmaki; Nadeem Akhtar; Zara J. Franklin; Judith Konantz; Gavin A. Bewick; Nikolay Ninov ABSTRACT Islet inflammation and cytokine production are implicated in pancreatic β-cell dysfunction and diabetes pathogenesis. However, we lack therapeutics to protect...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (11): dmm036210.
Published: 21 November 2018
... transporters (GLUTs), which have been identified as off-target molecules of the HIV protease inhibitor ritonavir. In this study, we examined the effect of ritonavir on inflammation in vitro and in vivo . Peripheral blood mononuclear cells (PBMCs) were activated with anti-CD3 in the presence or absence of...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (11): dmm035063.
Published: 16 November 2018
... inflammation was significantly elevated ( P <0.05) in the cecum of EHEC 278F2-colonized compared to E. coli MG1655-colonized C3H/HeN ASF mice. In addition, EHEC 278F2 differentially modulated inflammatory-associated genes in colonic tissue of C3H/HeN ASF mice compared to E. coli MG1655-colonized mice. This...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Dis Model Mech (2018) 11 (11): dmm035139.
Published: 16 November 2018
...Clémentine Le Magnen; Renu K. Virk; Aditya Dutta; Jaime Yeji Kim; Sukanya Panja; Zoila A. Lopez-Bujanda; Andrea Califano; Charles G. Drake; Antonina Mitrofanova; Cory Abate-Shen ABSTRACT Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes...
Includes: Supplementary data
Journal Articles
In collection:
Cancer
Dis Model Mech (2018) 11 (10): dmm036236.
Published: 24 October 2018
... , D. G. , et al. ( 2010 ). FcRγ activation regulates inflammation-associated squamous carcinogenesis . Cancer Cell   17 , 121 - 134 . 10.1016/j.ccr.2009.12.019 Balkwill , F. and Mantovani , A. ( 2001 ). Inflammation and cancer: back to virchow?   Lancet   357 , 539 - 545...
Includes: Supplementary data
Journal Articles
Dis Model Mech (2018) 11 (9): dmm035147.
Published: 28 August 2018
... transmitted infections through direct and indirect mechanisms involving inflammation and immune responses. The reproductive cycle can influence simian/human immunodeficiency virus (SHIV) infections in primates and HIV-1 infection in ex vivo cervical tissues from women. Exogenous hormones, such as those found...